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Journal of Investigative Medicine High Impact Case Reports

Journal of Investigative Medicine High Impact Case Reports

Published in Association with American Federation for Medical Research

eISSN: 23247096 | ISSN: 23247096 | Current volume: 6 | Current issue: 12

Journal Highlights

  • Indexed in: PubMed Central (PMC), Scopus, Google Scholar, and the DOAJ
  • Publication is subject to payment of an article processing charge (APC)
  • Submit here

Journal of Investigative Medicine High Impact Case Reports (HIC) is a peer-reviewed open access journal which focuses on high quality case reports representing a critical element of investigative medical science and an important avenue for career development. Please see the Aims and Scope tab for further information.

An official journal of the American Federation for Medical Research (AFMR).

This journal is a member of the Committee on Publication Ethics (COPE).

Submission information

Submit your manuscript today at

Please see the Submission Guidelines tab for more information on how to submit your article to the journal.

Open access article processing charge (APC) information

Publication in the journal is subject to payment of an article processing charge (APC). The APC serves to support the journal and ensures that articles are freely accessible online in perpetuity under a Creative Commons license.

The AFMR member APC for this journal is currently $350 USD.

The non-member APC for this journal is $750 USD.

The article processing charge (APC) is payable only if your article is accepted after peer review, before it is published. The APC is subject to taxes where applicable. Tax-exempt status can be indicated by providing appropriate registration numbers when payment is requested. Please see further details here.


Please direct any queries to

The AFMR is committed to enhancing the training and career development of our members and to furthering its mission to facilitate the conduct of research to improve medical care. Case reports represent an important avenue for trainees (interns, residents, and fellows) and early-stage faculty to demonstrate productive, scholarly activity.

Associate Editors
Richard Auchus, MD, PhD University of Michigan, Ann Arbor, MI, USA
Keith Colburn, MD Loma Linda University & Loma Linda VA Medical Center, Loma Linda, CA, USA
Robert J. Freishtat, MD, MPH Children's National Medical Center, Washington, DC, USA
Taylor Harrison, MD Emory University School of Medicine, Atlanta, GA, USA
Richard A. Lange, MD University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Suthat Liangpunsakul, MD Indiana University School of Medicine, Indianapolis, IN, USA
MingMing Ning, MD, MMsc Mass General Hospital/Harvard Medical School, Boston, MA, USA
Don Rockey, MD Medical University of South Carolina, Charleston, SC, USA
Peter Noel Van Buren, MD University of Texas Southwestern Medical Center, Dallas, TX, USA
Peter H. Wiernik, MD Cancer Research Foundation, Chappaqua, NY, USA
Editorial Board
Maneerat Chayanupatkul, MD Baylor College of Medicine, Houston, TX, USA
Everardo Cobos, MD, FACP Kern Medical Center, Bakersfield, CA, USA
Dawn Davis, MD, PhD University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Aidar Gosmanov, MD University of Tennessee Health Science Center, Memphis, TN, USA
Adriana Ioachimescu, MD, PhD, FACE Emory University School of Medicine, Atlanta, GA, USA
Armand Krikorian, MD Advocate Health Care, Oak Lawn, IL, USA
Chaitanya Pant, MD University of Kansas Medical Center, Kansas City, KS, USA
Neda Rasouli, MD University of Colorado, Denver, CO, USA
Allison Reiss, MD NYU Winthrop Hospital, Mineola, NY, USA
Florence Rothenberg, MD University of Cincinnati, Cincinnati, OH, USA
Leticia Ryan, MD, MPH Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Michael Schivo, MD University of California, Davis, CA, USA
Iuliana Shapira, MD SUNY Downstate Medical Center, Brooklyn, NY, USA
Abraham Thomas, MD NYU Langone Medical Center, New York, NY, USA
Kristina Utzschneider, MD University of Washington School of Medicine, Seattle, WA, USA
Cherry Wongtrakool, MD Emory University School of Medicine, Atlanta, GA, USA
Amir Zeki, MD University of California, Davis, CA, USA
  • Directory of Open Access Journals (DOAJ)
  • Google Scholar
  • ProQuest
  • PubMed Central (PMC)
  • Scopus
  • This Journal is a member of the Committee on Publication Ethics.

    This Journal recommends that authors follow the Uniform Requirements for Manuscripts Submitted to Biomedical
    formulated by the International Committee of Medical Journal Editors (ICMJE)

    Please read the guidelines below then visit the journal’s submission site to upload your manuscript. Please note that manuscripts not
    conforming to these guidelines may be returned.

    Only manuscripts of sufficient quality that meet the aims and scope Journal of Investigative Medicine High
    Impact Case Reports
    will be reviewed.

    As part of the submission process you will be required to warrant that you are submitting your original work,
    that you have the rights in the work, that you are submitting the work for first publication in the Journal and
    that it is not being considered for publication elsewhere and has not already been published elsewhere, and that
    you have obtained and can supply all necessary permissions for the reproduction of any copyright works not
    owned by you.

    Please Read the Manuscript Submission Guidelines below before submitting your manuscript here:


    1. Open Access
    2. Article processing charge (APC)
    3. What do we publish?
    4. Editorial policies
      4.1 Peer Review Policy
      4.2 Authorship
      4.3 Acknowledgements
      4.3.1 Writing assistance
      4.4 Funding
      4.5 Declaration of conflicting interests
      4.6 Research ethics and patient consent
      4.7 Clinical Trials
      4.8 Reporting guidelines
    5. Publishing policies
      5.1 Publication ethics
      5.1.1 Plagiarism
      5.1.2 Prior publication
      5.2 Contributor's publishing agreement
      5.3 Permissions
    6. Preparing your manuscript
      6.1 Word processing formats
      6.2 Artwork, figures and other graphics
      6.3 Supplementary material
      6.4 Journal layout
      6.5 Reference style
      6.6 English language editing services
    7. Submitting your manuscript
      7.1 How to submit your manuscript
      7.2 Title, keywords and abstracts
      7.3 Information required for completing your submission
    8. On acceptance and publication
      8.1 SAGE Production
      8.2 Continuous publication
    9. Further information

    1. Open Access

    Journal of Investigative Medicine High Impact Case Reports (JIMHICR) is an open access, peer-reviewed journal.
    Each article accepted by peer review is made freely available online immediately upon publication, is published
    under a Creative Commons license and will be hosted online in perpetuity. Publication costs of the journal are
    covered by the collection of article processing charges which are paid by the funder, institution or author of each
    manuscript upon acceptance. There is no charge for submitting a paper to the journal.

    For general information on open access at SAGE please visit the Open Access page or view our Open Access FAQs.

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    2. Article processing charge (APC)

    If, after peer review, your manuscript is accepted for publication, a one-time article processing charge (APC) is
    payable. This APC covers the cost of publication and ensures that your article will be freely available online in
    perpetuity under a Creative Commons license.

    The article processing charge (APC) for AFMR members is $250. The cost for non-members is $500.

    *Beginning January 1, 2018, the article processing charge (APC) for JIMHICR will change to $350 for AFMR
    members and $750 for non-members. This APC will apply to accepted articles with original submission dates of
    1/1/2018 and after. Accepted articles with original submission dates of 12/31/2017 and earlier will be assessed the
    old APC.

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    3. What do we publish?

    In general, Case Reports should not exceed 2500 words (excluding references). The word count (which includes all
    text including the abstract, manuscript, notes, tables, figures, etc) should appear on the title page. Exceptions will
    be considered on a case-by- case basis. Generally, proposed reviews should be less than 4000 words (excluding
    references). The submission of potential review articles should be discussed with the editorial office prior to

    Manuscripts should include an abstract of approximately 250 words, and, beneath the abstract, 4-5 keywords. All
    manuscripts should follow the style guidelines set forth in the American Medical Association Manual of Style (9th
    edition) ( Refer to drugs and therapeutic agents by their accepted generic or
    chemical names, and do not abbreviate them. Use code numbers only when a generic name is not yet available. In
    that case, supply the chemical name and a figure giving the chemical structure of the drug is required. Copyright or
    trade names of drugs should be capitalized and placed in parentheses after the name of the drug. Names and
    locations (city and state in USA; city and country outside USA) of manufacturers of drugs, supplies, or equipment
    cited in a manuscript are required to comply with trademark law and should be provided in parentheses. Units of
    measure should be expressed in the metric system, and temperatures should be expressed in degrees Celsius.
    Conventional units should be written as SI units as appropriate.

    Letters to the editor can be submitted on any topic relevant to the journal and are usually in response to an article published in the journal. They can suggest new subjects to be incorporated by the journal or commend and review papers published in the journal. We recommend that individuals considering submitting a letter to the editor should contact the editor in chief first to discuss their manuscript. Authors should be aware that letters to the editor are not always added to some databases/indexes. The standard article processing fee will apply, except if the letter addresses an issue on a published paper typically addressed through an expression of concern or retraction; in such cases no fee will apply.

    Patient anonymity and informed consent

    It is the author's responsibility to ensure that a patient's anonymity be carefully protected and to verify
    that any experimental investigation with human subjects reported in the manuscript was performed with
    informed consent and following all the guidelines for experimental investigation with human subjects
    required by the institution(s) with which all the authors are affiliated. Authors should mask patients' eyes
    and remove patients' names from figures unless they obtain written consent from the patients and
    submit written consent with the manuscript.


    For a list of standard abbreviations, consult the Council of Biology Editors Style Guide (available from the
    Council of Science Editors, 9650 Rockville Pike, Bethesda, MD 20814) or other standard sources. Write out
    the full term for each abbreviation at its first use unless it is a standard unit of measure.


    Art should be created/scanned and saved and submitted as either a TIFF (tagged image file format), an
    EPS (encapsulated PostScript) file, or a PPT (PowerPoint) file. Line art must have a resolution of at least
    1200 dpi (dots per inch), and electronic photographs; radiographs, CT scans, MRIs, all medical imaging,
    and all scanned images must have a resolution of at least 300 dpi. If fonts are used in the artwork, they
    must be converted to paths or outlines or they must be embedded in the files. Color images must be
    created/scanned and saved and submitted as CMYK files. Please note that artwork generated from office
    suite programs such as CorelDRAW and MS Word and artwork downloaded from the Internet (JPEG or GIF
    files) cannot be used. Cite figures consecutively on the site, and number them in the order in which they
    are discussed in the text of the manuscript.

    Figure legends

    Legends must be submitted for all figures. They should be brief and specific, and they should appear on a
    separate manuscript page place to follow the references. Use scale markers in the image for electron
    micrographs and indicate the type of stain used.

    Color figures

    The journal welcomes and encourages color figures and will publish them without charge to the author.


    Create tables using the table creating and editing feature of your word processing software (e.g., Word,
    WordPerfect). Do not use Excel or comparable spreadsheet programs. Group all tables at the end of the
    manuscript, or supply them together in a separate file. Cite tables consecutively in the text, and number
    them in that order. Key each on a separate sheet, and include the table title, appropriate column heads,
    and explanatory legends (including definitions of any abbreviations used). Do not embed tables within the
    body of the manuscript. They should be self-explanatory and should supplement, rather than duplicate,
    the material in the text.


    The authors are responsible for the accuracy of the references. Key the references (double-spaced) at the
    end of the manuscript. Cite the references in text in the order of appearance. Cite unpublished data—
    such as papers submitted but not yet accepted for publication and personal communications, including email
    communications—in parentheses in the text. If there are more than three authors, name only the
    first three authors and then use et al. Refer to the List of Journals Indexed in Index Medicus for
    abbreviations of journal names, or access the list at

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    4. Editorial policies

    4.1 Peer review policy

    The journal’s policy is to have manuscripts reviewed by two expert reviewers. JIMHICR utilizes a singleblind
    peer review process in which the reviewer’s name and information is withheld from the author. All
    manuscripts are reviewed as rapidly as possible, while maintaining rigor. Reviewers make comments to
    the author and recommendations to the Editor-in-Chief who then makes the final decision.
    As part of the submission process you will be asked to provide the names of three peers who could be
    called upon to review your manuscript. Recommended reviewers should be experts in their fields and
    should be able to provide an objective assessment of the manuscript. Please be aware of any conflicts of
    interest when recommending reviewers. Examples of conflicts of interest include (but are not limited to)
    the below:

    • The reviewer should have no prior knowledge of your submission
    • The reviewer should not have recently collaborated with any of the authors
    • Reviewer nominees from the same institution as any of the authors are not permitted

    Please note that the Editors are not obliged to invite any recommended/opposed reviewers to assess your

    The Editor or members of the Editorial Board may occasionally submit their own manuscripts for possible
    publication in the journal. In these cases, the peer review process will be managed by alternative
    members of the Board and the submitting Editor / Board member will have no involvement in the
    decision-making process.

    4.2 Authorship

    Papers should only be submitted for consideration once consent is given by all contributing authors.
    Those submitting papers should carefully check that all those whose work contributed to the paper are
    acknowledged as contributing authors.
    The list of authors should include all those who can legitimately claim authorship. This is all those who:

    (i) Made a substantial contribution to the concept or design of the work; or acquisition, analysis or
    interpretation of data,
    (ii) Drafted the article or revised it critically for important intellectual content,
    (iii) Approved the version to be published,
    (iv) Each author should have participated sufficiently in the work to take public responsibility for
    appropriate portions of the content.

    Authors should meet the conditions of all of the points above. Each author should have participated
    sufficiently in the work to take public responsibility for appropriate portions of the content.

    When a large, multicentre group has conducted the work, the group should identify the individuals who
    accept direct responsibility for the manuscript. These individuals should fully meet the criteria for

    Acquisition of funding, collection of data, or general supervision of the research group alone does not
    constitute authorship, although all contributors who do not meet the criteria for authorship should be
    listed in the Acknowledgments section. Please refer to the International Committee of Medical Journal
    Editors (ICMJE) authorship guidelines
    for more information on authorship.

    4.3 Acknowledgements

    All contributors who do not meet the criteria for authorship should be listed in an Acknowledgements
    section. Examples of those who might be acknowledged include a person who provided purely techincal
    help, or a department chair who provided only general support.

    4.3.1 Writing assistance

    Individuals who provided writing assistance, e.g. from a specialist communications company, do not
    qualify as authors and so should be included in the Acknowledgements section. Authors must disclose any
    writing assistance – including the individual’s name, company and level of input – and identify the entity
    that paid for this assistance.

    It is not necessary to disclose use of language polishing services.
    Any acknowledgements should appear first at the end of your article prior to your Declaration of
    Conflicting Interests (if applicable), any notes and your References.

    4.4 Funding

    JIMHICR requires all authors to acknowledge their funding in a consistent fashion under a separate
    heading. Please visit the Funding Acknowledgements page on the SAGE Journal Author Gateway to
    confirm the format of the acknowledgment text in the event of funding, or state that: This research
    received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

    4.5 Declaration of conflicting interests

    It is the policy of JIMHICR to require a declaration of conflicting interests from all authors enabling a
    statement to be carried within the paginated pages of all published articles.

    Please ensure that a ‘Declaration of Conflicting Interests’ statement is included at the end of your
    manuscript, after any acknowledgements and prior to the references. If no conflict exists, please state
    that ‘The Author(s) declare(s) that there is no conflict of interest’.

    For guidance on conflict of interest statements, please see the ICMJE recommendations.

    4.6 Research ethics and patient consent

    Medical research involving human subjects must be conducted according to the World Medical
    Association Declaration of Helsink

    Submitted manuscripts should conform to the ICMJE Recommendations for the Conduct, Reporting,
    Editing, and Publication of Scholarly Work in Medical Journals
    , and all papers reporting animal and/or
    human studies must state in the methods section that the relevant Ethics Committee or Institutional
    Review Board provided (or waived) approval. Please ensure that you have provided the full name and
    institution of the review committee, in addition to the approval number.

    For research articles, authors are also required to state in the methods section whether participants
    provided informed consent and whether the consent was written or verbal.

    Information on informed consent to report individual cases or case series should be included in the
    manuscript text, using examples from this template. A statement is required regarding whether written
    informed consent for patient information and images to be published was provided by the patient(s) or a 
    legally authorized representative. For examples of acceptable statements, please refer to JIMHICR’s IRB
    and Informed Consent document

    Please also refer to the ICMJE Recommendations for the Protection of Research Participants.

    4.7 Clinical trials

    JIMHICR conforms to the ICMJE requirement that clinical trials are registered in a WHO-approved public
    trials registry at or before the time of first patient enrolment as a condition of consideration for
    publication. The trial registry name and URL, and registration number must be included at the end of the

    4.8 Reporting guidelines

    The relevant EQUATOR Network reporting guidelines should be followed depending on the type of study.
    For example, all randomized controlled trials submitted for publication should include a completed
    Consolidated Standards of Reporting Trials (CONSORT) flow chart as a cited figure, and a completed
    CONSORT checklist as a supplementary file.

    Other resources can be found at NLM’s Research Reporting Guidelines and Initiatives.

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    5. Publishing policies

    5.1 Publication ethics

    SAGE is committed to upholding the integrity of the academic record. We encourage authors to refer to
    the Committee on Publication Ethics’ International Standards for Authors and view the Publication Ethics
    page on the SAGE Author Gateway.

    5.1.1 Plagiarism

    JIMHICR and SAGE take issues of copyright infringement, plagiarism or other breaches of best practice in
    publication very seriously. We seek to protect the rights of our authors and we always investigate claims
    of plagiarism or misuse of published articles. Equally, we seek to protect the reputation of the journal
    against malpractice. Submitted articles may be checked with duplication-checking software. Where an
    article, for example, is found to have plagiarized other work or included third-party copyright material
    without permission or with insufficient acknowledgement, or where the authorship of the article is
    contested, we reserve the right to take action including, but not limited to: publishing an erratum or
    corrigendum (correction); retracting the article; taking up the matter with the head of department or
    dean of the author's institution and/or relevant academic bodies or societies; or taking appropriate legal

    5.1.2 Prior publication

    If material has been previously published, it is not generally acceptable for publication in a SAGE journal.
    However, there are certain circumstances where previously published material can be considered for
    publication. Please refer to the guidance on the SAGE Author Gateway or if in doubt, contact the Editor at
    the address given below.

    5.2 Contributor's publishing agreement

    Before publication SAGE requires the author as the rights holder to sign a Journal Contributor’s Publishing
    Agreement. JIMHICR publishes manuscripts under Creative Commons licenses. The standard JIMHICR
    license is Creative Commons by Attribution (CC BY), which allows others to re-use the work without
    permission as long as the work is properly referenced. For more information, you are advised to visit
    SAGE's OA licenses page. For more information, you are advised to visit SAGE's OA licenses page.

    Alternative license arrangements are available, for example, to meet particular funder mandates, made at
    the author’s request. 

    5.3 Permissions

    Authors are responsible for obtaining permission from copyright holders for reproducing any illustrations,
    tables, figures or lengthy quotations previously published elsewhere. For further information including
    guidance on fair dealing for criticism and review, please visit our Frequently Asked Questions on the
    SAGE Journal Author Gateway.

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    6. Preparing your manuscript

    6.1 Word processing formats

    Preferred formats for the text and tables of your manuscript are Word DOC, RTF, XLS. LaTeX files are also
    accepted. The text should be double-spaced throughout and with a minimum of 3cm for left and right
    hand margins and 5cm at head and foot. Text should be standard 10 or 12 point. Word and (La)Tex
    templates are available on the Manuscript Submission Guidelines page of our Author Gateway.

    6.2 Artwork, figures and other graphics

    For guidance on the preparation of illustrations, pictures and graphs in electronic format, please visit
    SAGE’s Manuscript Submission Guidelines.

    Figures supplied in color will appear in color online.

    6.3 Supplementary material

    This journal is able to host additional materials online (e.g. datasets, podcasts, videos, images etc)
    alongside the full-text of the article. These will be subjected to peer-review alongside the article. For
    more information please refer to our guidelines on submitting supplementary files, which can be found
    within our Manuscript Submission Guidelines page. 

    6.4 Journal layout

    JIMHICR conforms to the SAGE house style. Click here to review guidelines on SAGE House Style. 

    6.5 Reference style

    JIMHICR adheres to the SAGE Vancouver reference style. Please review the guidelines on SAGE Vancouver
    to ensure your manuscript conforms to this reference style.

    If you use EndNote to manage references, you can download the SAGE Vancouver output file here.

    6.6 English language editing services

    Authors seeking assistance with English language editing, translation, or figure and manuscript formatting
    to fit the journal’s specifications should consider using SAGE Language Services. Visit SAGE Language
    on our Journal Author Gateway for further information. 

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    7. Submitting your manuscript

    7.1 How to submit your manuscript

    JIMHICR is hosted on SAGE Track, a web based online submission and peer review system powered by
    ScholarOne™ Manuscripts. Visit to login and submit your
    article online.

    IMPORTANT: Please check whether you already have an account in the system before trying to create a
    new one. If you have reviewed or authored for the journal in the past year it is likely that you will have
    had an account created. For further guidance on submitting your manuscript online please visit
    ScholarOne Online Help.

    7.2 Title, keywords and abstracts

    Please supply a title, short title, an abstract and keywords to accompany your article. The title, keywords
    and abstract are key to ensuring readers find your article online through online search engines such as
    Google. Please refer to the information and guidance on how best to title your article, write your abstract
    and select your keywords by visiting the SAGE Journal Author Gateway for guidelines on How to Help
    Readers Find Your Article Online

    7.3 Information required for completing your submission

    Provide full contact details for the corresponding author including email, mailing address and telephone
    numbers. Academic affiliations are required for all co-authors. 

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    8. On acceptance and publication

    If your paper is accepted for publication after peer review, you will first be asked to complete the contributor’s
    publishing agreement. Once your manuscript files have been check for SAGE Production, the corresponding author
    will be asked to pay the article processing charge (APC) via a payment link. Once the APC has been processed, your
    article will be prepared for publication and can appear online within an average of 30 days. Please note that no
    production work will occur on your paper until the APC has been received.

    8.1 SAGE Production

    When your paper enters the SAGE Production system, your paper will be issued with a 6 digit ID number.
    Your SAGE Production Editor will keep you informed as to your article’s progress throughout the
    production process. Proofs will be sent by email attachment to the corresponding author and should be
    returned promptly. Authors are reminded to check their proofs carefully to confirm that all author
    information, including names, affiliations, sequence and contact details are correct, and that Funding and
    Conflict of Interest statements, if any, are accurate.

    8.2 Online publication

    One of the many benefits of publishing your research in an open access journal is the speed to
    publication. Your article will be published online in a fully citable form with a DOI number as soon as it has
    completed the production process. At this time it will be completely free to view and download for all.
    Check the ‘Latest Articles’ tab on the journal website for the latest published content. 

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    9. Further information

    Any correspondence, queries or additional requests for information on the Manuscript Submission process should
    be sent to Amanda Beaini at

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