Annals of Clinical Biochemistry
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Annals of Clinical Biochemistry

An international journal of biochemistry and laboratory medicine
2015 Impact Factor: 2.119
2015 Ranking: 11/30 in Medical Laboratory Technology
2016 Release of Journal Citation Reports, Source: 2015 Web of Science Data

Editor
Edmund J Lamb East Kent Hospitals University NHS Foundation Trust, Canterbury, UK
Deputy Editor
Michael J Murphy Ninewells Hospital & Medical School, Dundee, UK


eISSN: 17581001| ISSN: 00045632|Current volume: 53|Current issue: 5 Frequency: Bi-monthly

Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine.

Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal's scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals.

Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).

The AACB (Australasian Association of Clinical Biochemists) promotes subscriptions to the Annals to their members via a mutual agreement.

This journal is a member of the Committee on Publication Ethics (COPE)

Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine.

Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal's scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals.

Associations and Societies
The Annals Of Clinical Biochemistry is published by SAGE Publications on behalf of the Association for Clinical Biochemistry and Laboratory Medicine.

Annals is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).

The AACB (Australasian Association of Clinical Biochemists) promotes subscriptions to the Annals to their members via a mutual agreement. 

Associate Editors
Michael J Bennett Philadelphia, USA
Rien MA Blankenstein Amsterdam, the Netherlands
Martin A Crook London, UK
Julie Davies Hereford, UK
Simon Fleming Truro, UK
John W Honour Thornbury, UK
Katsuyuki Nakajima Gunma, Japan
Maurice O'Kane Londonderry, UK
Dr Melanie Percy Belfast City Hospital, UK
Anthony Rowbottom Preston, UK
Samuel Vasikaran Perth, Australia
Philip R Wenham Fife, UK
Book Review Editor
Andrew Day Bristol, UK
Statistical Advisor
Robert West Leeds, UK
Editorial Board
A Almeida Salamanca, Spain
J H Barth Leeds, UK
P O Collinson London, UK
R Erasmus Cape Town, South Africa
D Gaze London, UK
D G Grenache Salt Lake City, USA
E Hall Canterbury, UK
S Holding Hull, UK
B Jones London, UK
B G Keevil Manchester, UK
E S Kilpatrick Doha, Qatar
V Palicka Hradec Králové, Czech Republic
D Ready London, UK
G Rumsby London, UK
L Sandle Manchester, UK
K Spencer Romford, UK
Association for Clinical Biochemistry
BM Harris Bath, UK
Prof ES Kilpatrick Hull, UK
P Newland Liverpool, UK
Dr M Thomas London, UK
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    1. Article types
    2. Editorial Policies
      2.1 Peer review policy
      2.2 Authorship
      2.3 Competing interests and other declarations
      2.4 Research ethics and patient consent
      2.5 Clinical Trials
      2.6 Reporting Guidelines
      2.7 Statistical analysis
      2.8 Abbreviations and units
    3. Publishing Policies
      3.1 Publication Ethics
      3.2 Contributor's publishing agreement
      3.3 Open Access and author archiving
      3.4 Permissions
    4. Preparing your manuscript
      4.1 Word processing formats
      4.2 Artwork, figures and other graphics
      4.3 Supplementary material
      4.4 Journal layout
      4.5 Reference style
      4.6 English language editing services
    5. Submitting your manuscript
    6. On acceptance and publication
      6.1 SAGE Production
      6.2 Access to your published article
      6.3 Annals Express
      6.4 Online First publication
    7. Further Information

    This Journal is a member of the Committee on Publication Ethics.
    These instructions comply with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals formulated by the International Committee of Medical Journal Editors (ICMJE).

    There are no fees payable to submit or publish in this journal.

    Please read the guidelines below then visit the Journal’s submission site http://mc.manuscriptcentral.com/acb to upload your manuscript. All articles submitted to the Annals of Clinical Biochemistry must comply with the instructions below. Failure to do so will result in return of the manuscript and possible delay in publication.

    Only manuscripts of sufficient quality that meet the aims and scope of the Annals will be reviewed.

    As part of the submission process you will be required to warrant that you are submitting your original work, that you have the rights in the work, that you are submitting the work for first publication in the Journal and that it is not being considered for publication elsewhere and has not already been published elsewhere, and that you have obtained and can supply all necessary permissions for the reproduction of any copyright works not owned by you.

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    1. Article types

    Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine.

    Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal's scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals.

    Editorials

    Articles referring to research published elsewhere in that issue of the journal, or to important events in clinical biochemistry. Editorials are generally invited and do not include an Abstract.

    Personal Views
    Articles pertinent to clinical and scientific developments or to the practice of clinical biochemistry. Personal Views are generally invited and should be less than 3000 words, excluding the abstract and references.

    Review Articles
    Articles of a substantial and topical nature. Review Articles are generally invited and should be less than 6000 words, excluding the abstract and references.

    Research Articles
    Articles describing substantial original research that falls within the scope of the journal. These should less than 5000 words, excluding the abstract and references, and have no more than six figures and tables. Structured headings are required.

    Short Reports
    Brief technical notes and preliminary communications. These should be less than 1000 words, excluding the abstract and references, and have only one small figure or table and no more than six references. Structured headings, including a conclusion, are desirable.

    Case Reports
    Articles describing clinical cases that have significant novel original observations, are instructive, include adequate methodological details and provide conclusions. These should be less than 2000 words, excluding the abstract and references, and have no more than two figures and tables. Structured headings are desirable. Please note the below comments regarding obtaining written informed consent.

    Letters to the Editor
    Letters arise normally but not exclusively from papers published in this and other scientific journals. These are usually less than 500 words.

    Journal Watch

    Short reviews of recently published articles of significant relevance to laboratory medicine. Potential contributors are advised to contact the Journal Watch coordinator at annals@acb.org to obtain the document template required.

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    2. Editorial policies

    2.1 Peer review policy

    Peer review policy
    All papers submitted for publication undergo peer review.

    Covering letter
    The covering letter is important. To help the Editor in his preliminary evaluation, please indicate why you think the paper suitable for publication. If your paper should be considered for fast-track publication, please explain why.

    As part of the submission process you will be asked to provide the names of peers who could be called upon to review your manuscript. Recommended reviewers should be experts in their fields and should be able to provide an objective assessment of the manuscript. Please be aware of any conflicts of interest when recommending reviewers. Examples of conflicts of interest include (but are not limited to) the below: 

    • The reviewer should have no prior knowledge of your submission
    • The reviewer should not have recently collaborated with any of the authors
    • Reviewer nominees from the same institution as any of the authors are not permitted

    Please note that the Editors are not obliged to invite any recommended/opposed reviewers to assess your manuscript.

    2.2 Authorship

    Papers should only be submitted for consideration once consent is given by all contributing authors. Those submitting papers should carefully check that all those whose work contributed to the paper are acknowledged as contributing authors.

    The list of authors should include all those who can legitimately claim authorship. This is all those who:

    (i) Made a substantial contribution to the concept or design of the work; or acquisition, analysis or interpretation of data,
    (ii) Drafted the article or revised it critically for important intellectual content,
    (iii) Approved the version to be published,
    (iv) Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content.

    Authors should meet the conditions of all of the points above. Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content.
    When a large, multicentre group has conducted the work, the group should identify the individuals who accept direct responsibility for the manuscript. These individuals should fully meet the criteria for authorship.

    Acquisition of funding, collection of data, or general supervision of the research group alone does not constitute authorship, although all contributors who do not meet the criteria for authorship should be listed in the Acknowledgments section. Please refer to the International Committee of Medical Journal Editors (ICMJE) authorship guidelines for more information on authorship.

    All contributors who do not meet the criteria for authorship should be listed in an Acknowledgements section. Examples of those who might be acknowledged include a person who provided purely technical help, or a department chair who provided only general support.

    Individuals who provided writing assistance, e.g. from a specialist communciations company, do not qualify as authors and so should be included in the Acknowledgements section. Authors must disclose any writing assistance – including the individual’s name, company and level of input – and identify the entity that paid for this assistance”). It is not necessary to disclose use of language polishing services.

    2.3 Competing interests and other declarations

    All authors are required to declare any conflicts of interest when submitting papers for publication. Declarations of funding sources, a guarantor and a statement of contributorship are also required.

    Please visit the Funding Acknowledgements page on the SAGE Journal Author Gateway to confirm the format of the acknowledgment text in the event of funding, or state that: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. 

    The guarantor is the person willing to take full responsibility for the article, including for the accuracy and appropriateness of the reference list. This will often be the most senior member of the research group and is commonly also the author for correspondence. Please state author names as initials.

    For example:

    Declaration of competing interests: HG is an employee of Statins Incorp. EF has received grants from Globescape plc. LM provides consultative advice to Lab Tests Ltd

    Funding: This research was funded by the University of York

    Ethical approval: The ethics committee of Northern Yorkshire approved this study (REC number: GH23335H)
    Guarantor: EF

    Contributorship: LM and HG researched literature and conceived the study. EF was involved in protocol development, gaining ethical approval, patient recruitment and data analysis. AB wrote the first draft of the manuscript. All authors reviewed and edited the manuscript and approved the final version of the manuscript

    Acknowledgements: We would like to thank Sarah Powells for her assistance and guidance in this research. We would also like to thank Globescape plc for providing reagents at a reduced cost.

    For additional guidance on conflict of interest statements, please see the ICMJE recommendations here

    2.4 Research ethics and patient consent

    Medical research involving human subjects must be conducted according to the World Medical Association Declaration of Helsinki

    Submitted manuscripts should conform to the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals, and all papers reporting human studies must state in the methods section that the relevant Ethics Committee or Institutional Review Board provided (or waived) approval. Please ensure that you have provided the full name and institution of the review committee and an Ethics Committee reference number.

    Any article containing identifiable patient information must be accompanied by a letter from the authors confirming that the patient has given written informed consent to publication. A statement to this effect should also be included in the Ethical approval section of the declarations. Patient’s names, initials or hospital numbers should never be published in written descriptions. Other information (age, gender, race, etc) should only be included where it is essential for scientific purposes and the patient (or parent or guardian) has given written informed consent. The Editors may also ask authors to remove personal information that, whilst interesting and colourful, does not add to the substance of an article, but does increase the likelihood of parties being identified. If there is any doubt about whether or not information is identifiable, the Editors are happy to discuss this before an article is submitted. Reviewers will also be asked to take careful account of issues relating to patient confidentiality when reviewing articles.

    Case studies are not the only kinds of article to which this rule will be applied, but they will be subject to additional scrutiny. Not only should submissions be accompanied by the letter confirming written informed consent, but the Editors also expect to be informed about the measures that have been taken to anonymise the details that could have led to parties being identified. They also reserve the right to work with the authors to make additional anonymising changes as they or the reviewers see fit.

    In order to ensure that valuable and novel issues are aired, the Editors will sometimes consider publishing cases studies that contain potentially identifiable information where it has been impossible or clearly undesirable to seek consent from relevant parties. However, given the strong preference for consent having been sought and obtained the reasons for not seeking consent must be compelling, and the public interest arguments for publishing the case must be powerful. In cases where consent has not been obtained, the authors must provide a statement from a Medical Director or equivalent that the hospital or medical centre is happy for the case to be published.

    Please do not submit the patient’s actual written informed consent with your article, as this in itself breaches the patient’s confidentiality. The Journal requests that you confirm to us, in writing, that you have obtained written informed consent but the written consent itself should be held by the authors/investigators themselves, for example in a patients hospital record. The confirmatory letter may be uploaded with your submission as a supplementary file.

    A template form for obtaining written informed consent can be obtained here.

    Please also refer to the ICMJE Recommendations for the Protection of Research Participants

    2.5 Clinical trials

    Annals of Clinical Biochemistry conforms to the ICMJE requirement that clinical trials are registered in a WHO-approved public trials registry at or before the time of first patient enrolment as a condition of consideration for publication. The trial registry name and URL, and registration number must be included at the end of the abstract.

    2.6 Reporting guidelines

    The relevant EQUATOR Network reporting guidelines should be followed depending on the type of study. For example, all randomized controlled trials submitted for publication should include a completed Consolidated Standards of Reporting Trials (CONSORT) flow chart as a cited figure, and a completed CONSORT checklist as a supplementary file.

    Other resources can be found at NLM’s Research Reporting Guidelines and Initiatives

    2.7 Statistical analysis

    If preparing statistical data for publication, please read these statistical guidelines. Please note that these guidelines are not a substitute for the detailed guidance required to design a study or perform a statistical analysis.

    2.8 Abbreviations and units

    Abbreviations: Symbols and abbreviations should be those currently in use. Authors should not create new abbreviations and acronyms. Please refer to the Style Notes for Authors for additional guidance on abbreviations used by the Annals.

    Units:  All measurements should be expressed in SI units.

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    3. Publishing policies

    3.1 Publication ethics

    SAGE is committed to upholding the integrity of the academic record. We encourage authors to refer to the Committee on Publication Ethics’ International Standards for Authors and view the Publication Ethics page on the SAGE Author Gateway

    3.1.1 Plagiarism

    Annals of Clinical Biochemistry and SAGE take issues of copyright infringement, plagiarism or other breaches of best practice in publication very seriously. We seek to protect the rights of our authors and we always investigate claims of plagiarism or misuse of published articles. Equally, we seek to protect the reputation of the journal against malpractice. Submitted articles will be checked with duplication-checking software. Where an article, for example, is found to have plagiarised other work or included third-party copyright material without permission or with insufficient acknowledgement, or where the authorship of the article is contested, we reserve the right to take action including, but not limited to: publishing an erratum or corrigendum (correction); retracting the article; taking up the matter with the head of department or dean of the author's institution and/or relevant academic bodies or societies; or taking appropriate legal action.

    3.2 Contributor's publishing agreement

    Before publication, SAGE requires the author as the rights holder to sign a Journal Contributor’s Publishing Agreement. SAGE’s Journal Contributor’s Publishing Agreement is an exclusive licence agreement which means that the author retains copyright in the work but grants SAGE the sole and exclusive right and licence to publish for the full legal term of copyright. Exceptions may exist where an assignment of copyright is required or preferred by a proprietor other than SAGE. In this case copyright in the work will be assigned from the author to the society. For more information please visit our Frequently Asked Questions on the SAGE Journal Author Gateway.

    3.3 Open Access and author archiving

    Annals of Clinical Biochemistry offers optional open access publishing via the SAGE Choice programme. For more information please visit the SAGE Choice website. For information on funding body compliance, and depositing your article in repositories, please visit SAGE Publishing Policies on our Journal Author Gateway.

    3.4 Permissions

    Authors are responsible for obtaining permission from copyright holders for reproducing any illustrations, tables, figures or lengthy quotations previously published elsewhere. For further information including guidance on fair dealing for criticism and review, please visit our Frequently Asked Questions on the SAGE Journal Author Gateway

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    4. Preparing your manuscript

    4.1 Word processing formats

    Preferred formats for the text and tables of your manuscript are Word DOC, RTF, XLS. LaTeX files are also accepted. The text should be double-spaced throughout and with a minimum of 3cm for left and right hand margins and 5cm at head and foot. Text should be standard 10 or 12 point. Word and (La)Tex templates are available on the Manuscript Submission Guidelines page of our Author Gateway.

    4.2 Artwork, figures and other graphics

    For guidance on the preparation of illustrations, pictures and graphs in electronic format, please visit SAGE’s Manuscript Submission Guidelines  
    Figures supplied in colour will appear in colour online regardless of whether or not these illustrations are reproduced in colour in the printed version. For specifically requested colour reproduction in print, you will receive information regarding the costs from SAGE after receipt of your accepted article.

    4.3 Supplementary material

    This journal is able to host additional materials online (e.g. datasets, podcasts, videos, images etc) alongside the full-text of the article. These will be subjected to peer-review alongside the article.  For more information please refer to our guidelines on submitting supplementary files, which can be found within our Manuscript Submission Guidelines page.

    4.4 Journal layout

    Annals of Clinical Biochemistry conforms to the SAGE house style.  Click here to review guidelines on SAGE UK House Style.

    4.5 Reference style

    Annals of Clinical Biochemistry adheres to the SAGE Vancouver reference style. Click here to review the guidelines on SAGE Vancouver to ensure your manuscript conforms to this reference style.

    If you use EndNote to manage references, you can download the SAGE Harvard output file here and the SAGE Vancouver output file here

    4.6 English language editing services

    Authors seeking assistance with English language editing, translation, or figure and manuscript formatting to fit the journal’s specifications should consider using SAGE Language Services. Visit SAGE Language Services on our Journal Author Gateway for further information.

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    5. Submitting your manuscript

    Only manuscripts submitted via the online manuscript submission and peer review site, which can be found at http://mc.manuscriptcentral.com/acb will be considered for publication.

    All submissions must be in English.

    IMPORTANT: Please check whether you already have an account in the system before trying to create a new one. If you have reviewed or authored for the journal in the past year it is likely that you will have had an account created.  For further guidance on submitting your manuscript online please visit ScholarOne Online Help.

    Tables and figures may be submitted as separate files, in which case the files should be uploaded in the following order: (1) main text, including title page, abstract and references; (2) tables; (3) figures; (4) supplementary files.

    Each manuscript should contain:

    (i) Title page:the first page should contain the full title of the manuscript, the author(s) name(s) and affiliation(s), the name, postal and email addresses of the author for correspondence, a full list of declarations, as well as the abstract word count and the actual word count (excluding the abstract and references).

    The title should be concise and informative, accurately indicating the content of the article. The correct order for declarations is: competing interests, funding, ethical approval (including reference number), guarantor, contributorship, acknowledgements.

    (ii) Abstract: a structured abstract of no more than 250 words must accompany all Research Articles and Short Reports. The abstract should use four headings: Background (context and rationale); Methods (type of study, patients, materials, techniques); Results (main numerical data and statistical information); and Conclusions (main objective and verifiable conclusions). Reviews, Personal Views and Case Reports should be accompanied by an unstructured abstract of up to 250 words. Letters to the Editor do not require an abstract.

    (iii) Keywords: please supply between three and seven keywords/phrases.
    The title, keywords and abstract are key to ensuring readers find your article online through online search engines such as Google. Please refer to the information and guidance on how best to title your article, write your abstract and select your keywords by visiting the SAGE Journal Author Gateway for guidelines on How to Help Readers Find Your Article Online

    Provide full contact details for the corresponding author including email, mailing address and telephone numbers. Academic affiliations are required for all co-authors.

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    6. On acceptance and publication

    6.1 SAGE Production

    Your SAGE Production Editor will keep you informed as to your article’s progress throughout the production process. Proofs will be sent by PDF to the corresponding author and should be returned promptly.

    6.2 Access to your published article

    SAGE provides authors with online access to their final article.

    6.3 Annals Express

    The Annals now makes articles that have been accepted following peer review available immediately, before they have gone through the production process at SAGE. These accepted manuscripts are published within the Online First programme on SAGE Journals Online upon peer review acceptance for publication and before copyediting, typesetting and other value added by SAGE.

    6.4 Online First publication

    Online First allows final revision articles (completed articles in queue for assignment to an upcoming issue) to be published online prior to their inclusion in a final journal issue which significantly reduces the lead time between submission and publication. For more information please visit our Online First Fact Sheet

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    7. Further Information

    Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the Editorial Office: annals@acb.org.uk

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