Therapeutic Advances in Chronic Disease

Therapeutic Advances in Chronic Disease

Managing Editor
Gordon Mallarkey SAGE Publications Ltd, UK
Associate Editors
Ian Beales Norfolk and Norwich University Hospital, Norfolk, UK
Emma Clark University of Bristol, Bristol, UK
Riccardo Polosa Az. Ospedaliero-Universitaria Vittorio Emanuele, Italy
Shahrad Taheri Weill Cornell Medical College, Doha, Qatar

eISSN: 20406231 | ISSN: 20406223 | Current volume: 7 | Current issue: 5 Frequency: Bi-monthly

Therapeutic Advances in Chronic Disease publishes the highest quality peer-reviewed research, reviews and scholarly comment in the drug treatment of all chronic diseases (excluding cancer). You can access the journal online for free at

The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers involved in the medical treatment of chronic disease, providing a forum in print and online for publishing the highest quality articles in this area. The editors welcome articles of current interest on research across areas of drug treatment of all major chronic diseases (excluding cancer, which is covered in Therapeutic Advances in Medical Oncology).

It publishes expert opinion reviews (including single-drug and drug class reviews), narrative reviews and analysis of published guidelines (as editorials or reviews). Original research manuscripts of well-designed trials are also welcomed that show drug or drug class efficacy in a particular disease or therapeutic area. The journal strongly encourages the submission of original research with positive or negative results.

The journal adheres to a blind review process in which the reviewer's name is routinely withheld from the author unless the reviewer requests a preference for their identity to be revealed. Manuscripts are reviewed by at least two referees - a first editorial decision is generally reached within 3 weeks of submission. Online publication of articles occurs within 7 weeks from acceptance. Further information for contributors is provided on the back pages of each issue and online.

Unofficial impact factor for 2014, based on citation data from Thomson Reuters Web of Science®:  2.63

For all commercial sales and sponsorship enquiries, including advertising, reprints and supplements, please contact:
Commercial Sales Team, London, UK
Tel. +44 20 7336 1205

This journal is a member of the Committee on Publication Ethics (COPE).

Therapeutic Advances in Chronic Disease covers the drug treatment of all major chronic diseases (excluding cancer, which is covered in a sister publication).

It publishes guidance on which drugs to use and when (i.e. expert opinion reviews, narrative reviews, analysis of published guidelines (editorials or reviews). Single-drug reviews (including brief reviews of new drugs) and drug class reviews are also published with the aim of providing practically relevant information to the doctor group that treats such patients.

Original research manuscripts of well-designed trials are also welcomed that show drug or drug class efficacy in a particular disease.

The journal adheres to a blinded review process in which the reviewer's name is routinely withheld from the author unless the reviewer requests a preference for their identity to be revealed. Manuscripts are reviewed by at least two referees - a first editorial decision is generally reached within 3 weeks of submission. Further information for contributors are provided on the back pages of each issue.

1. The purpose of the Journal is to publish (in the English language) editorials, reviews and original research articles, that have been judged worthy of publication by appropriate specialists and accepted by the Editor-in-Chief, on clinical studies relating to chronic disease. The Journal is for all professionals with special expertise or interest in chronic disease treatment and management, and is a forum for all views on this subject. The Editor-in-Chief welcomes articles of current interest on original research and reviews.

2. The Journal will be international in the sense that it will seek, wherever possible, to publish material from authors with an international reputation and articles that are of interest to an international audience.

3. In pursuit of the above the journal shall:

(i) draw on and include high quality work from the international community of scholars including those in the major countries of Europe, Australasia, the United States, other parts of the Americas, countries in the Third World and elsewhere with due representation for considerations of the readership. The Journal shall include work representing the major areas of interest in contemporary research in chronic disease.

(ii) avoid bias in favour of the interests of particular schools or directions of research or particular political or narrow disciplinary objectives to the exclusion of others;

(iii) ensure that articles are written in a terminology and style which makes them intelligible, not merely within the context of a particular discipline or abstract mode, but across the domain of relevant disciplines.

Editorial Board
Kathryn Abel University of Manchester, UK
Bo Abrahamsen Copenhagen University Hospital Gentofte, Hellerup, Denmark
Frazer H Anderson Southampton University, UK
Riitta Antikainen Oulu City Hospital, Finland
Jonathan Bayly University of Derby, Derby, UK
Michael Berk University of Melbourne, Australia
Michael Blackburn University of Texas, USA
Xavier Calvet Hospital de Sabadell, Spain
Rudolph Castellani University of Maryland, USA
Gemma Casadesus Case Western Reserve University, USA
Mario Cazzola University of Rome "Tor Vergata", Rome, Italy
Pascal Chanez University of the Mediterranian, France
Emma Clark University of Bristol, Bristol, UK
Martin Connolly University of Auckland, New Zealand
Leonardo M. Fabbri University of Modena and Reggio Emilia, Italy
Serge Ferrari Hopitaux Universitaires de Geneve, Switzerland
Andrea Fox Chemical Abstracts Service, USA
Stephen Gallacher Southern General Hospital, Scotland
Javier P. Gisbert La Princesa University Hospital, Spain
Neil Gittoes University Hospitals Birmingham, UK
Nicola A Hanania Baylor College of Medicine, Houston, USA
Elaine Hylek Boston Medical Center, Boston, MA, USA
Peter Joyce Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
Hyoung-gon Lee Case Western Reserve University, Cleveland, OH, USA
Colleen Loo St George Hospital, Australia
Ricardo Maccioni University of Chile Medical School, Chile
Arduino Mangoni Flinders University, Adelaide, Australia
Tahir Masud Nottingham University, Nottingham, UK
Eugene McCloskey University of Sheffield, UK
Terry McCormack Whitby Medical Practice, UK
Andrew McIntosh University of Edinborgh, UK
Paula Moreira University of Coimbra, Portugal
Jaymin Morjaria University of Hull, Cottingham, UK
Bjorn Moum Faculty Div. Aker University Hospital, Norway
Anthony O'Conner Adelaide and Meath Hospital, Ireland
Pierluigi Paggiaro University of Pisa, Pisa, Italy
Sanjeev Patel St Helier University Hospital, UK
Ruth Peters Imperial College, London, UK
James B. Potash Mood Disorders Centre, USA
Craig Ritchie Imperial College London, UK
Shun Shinohama Sapporo Medical University, Japan
Thomas Schulze Georg-August-University Gvttingen , Germany
Massimo Tabaton University of Genoa, Genoa, Italy
Lakshmi Yatham University of British Columbia, Canada
Xiongwei Zhu Case Western Reserve University, USA
  • Chemical Abstracts Service (CAS)
  • Medscape
  • PubMed
  • Thomson Reuters: Emerging Sources Citation Index (ESCI)
    1. Correspondence and online submission
    2. Publication categories
    3. Writing your manuscript
    4. Reference style
      4.1 Corresponding author contact details
    5. Research ethics
    6. Publication statement
    7. Peer review statement
    8. Journal contributor’s publishing agreement
    9. Declaration of conflicting interests policy
    10. Authorship
    11. Plagiarism Policy
    12. Writing Assistance
    13. Funding Acknowledgement
    14. Informed consent
    15. Permissions
    16. After acceptance
      16.1 Proofs
      16.2 E-Prints and complimentary copies
      16.3 SAGE production
      16.4 OnlineFirst publication
      16.5 SAGE Choice


    1. Correspondence and online submission

    All correspondence, including notification of the Editor's decision and requests for revisions, will be by e-mail. All manuscript submissions should be made online at the journal’s respective SAGEtrack website:

     - If you have not used the site before, please click the 'Create Account' link and follow the on-screen instructions.
     - If you have previously used the journal’s SAGEtrack site, either as an author or a referee, please use your existing login details. If you do not know your login details, simply enter your email address in the 'Forgot your password' box and you will receive instructions on how to log in right away.

    Once you have logged in to the site, please select 'Author Center', then 'Click here to submit a manuscript'.

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    2. Publication categories

    The Therapeutic Advances journals consider the following kinds of article for publication:

    1. Original Research Articles, describing new experimental findings, or ana;yses (e.g. posthoc, subgroup, meta-analysis where an overall statistic is derived).
    2. Review Articles. The Editors wish to encourage the following types of review, but request that authors contact them in advance:

    (a) general reviews that provide a synthesis of an area that fits within the aims and scope of the journal;
    (b) perspectives - brief overviews, which are 6-8 printed pages in length including references, that address important new areas of general interest;
    (c) critiques - focused and provocative reviews that are followed by a number of invited commentaries, with a concluding reply from the main author;
    (d) structured case reports - outlining an interesting case, and including a full review of the pertinent literature and a section on implications for clinical care;
    (e) case series studies or clinical series – descriptive study of a small group of patients (with the same disease or receiving the same treatment) including a full review of the pertinent literature and a section on implications for clinical care;

    3. Letters to the Editor; these also include brief case reports. These should be as concise as possible and up to 1000 words.

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    3. Writing your manuscript

    The Therapeutic Advances series subscribes predominantly to the editorial preferences expressed in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals [ICMJE, 2007] issued by the International Committee of Medical Journal Editors. Each page should be numbered and identified with a shortened version of the title.

    Abstract - The abstract should accurately and concisely reflect the content of the article, and should be limited to 300 words. Original research articles should include structured abstracts, using the four headings Objectives, Methods, Results, and Conclusions. Please avoid reference citations and undefined abbreviations in the abstract. 
    Review articles do not require structured abstracts.
    Key words (or key word phrases) 2-8 to accompany the abstract. They should, if possible, be drawn from the MeSH list of Index Medicus and be chosen with a view to useful cross-indexing of the article.

    Main text - Subdivide your article with appropriate headings. Use no more than two levels of subheading.

    Acknowledgements - Between the end of the main text and the start of the references section, please acknowledge sources of financial and material support, and those who have contributed intellectually, with their consent.
    See guidelines for: Funding Acknowledgement

    Tables must all be cited in the text, carry brief but complete titles, and be numbered consecutively with Arabic numerals. Keep rules (horizontal only) to a minimum.

    Figures should be supplied as vector-based, separate .eps files (not as .tiff files, and not only inserted in the Word or pdf file), with a resolution of 300dpi (dots per inch). They should be used with discretion to clarify (not duplicate) the text. They should be cited in the text, using arabic numerals, and their approximate location in the paper clearly indicated [Figure 1 near here]. They should, for preference, be supplied at reproduction size (single- or double-column width), and lettering should be no smaller than 8pt type.
    Legends should be explanatory but succinct. They should carry the arabic numerals applicable to the figures, and be provided as a separate typed list at the end of the paper, along with the figures themselves.

    Units of measurement should be expressed in SI and metric units; older conventional units may be added in parentheses.

    Nomenclature: Use the generic or chemical name of any drug, in lower case; the specific trade name (capitalized) may be given in parentheses after the first text reference.

    Standard Abbreviations and symbols should be used, then defined in full in the first instance unless they are standard units of measurement. Avoid any use of abbreviations in the article title and abstract.

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    4. Reference Style

    The Therapeutic Advances series uses a modified Harvard reference style whereby we cite the first 6 authors in the reference section (examples below). If you use Endnote, you may download plug-ins (see below) so that you can format your references correctly.

    EndNote Users: Click here to download the journal's style file (.ens). 
    In the main text, place each author in square parentheses, throughout the text, tables, and legends: [Author A, 2004]; [Author A and Author B, 2006]; [Author et al. 2007] 

    In the reference list, all references appear alphabetically. Please list up to 6 authors, or 6 authors followed by et al
    Authors: List each author's last name and initials; full first names are not included. For books with chapters written by individual authors, list the authors of the chapter first, then the chapter title, followed by 'In', the editors' names, and the book title, the publisher, and the location. 
    Book titles, chapter titles: Capitalize the first letter of the first word in the title. The rest of the title is in lower-case, with the exception of proper names (see example 3 below). Do not underline the title; do not use italics.

    Example - Journal citations

    Abduljawad, K.A.J. and Langley, R.W. (2001) Article title here. J Psychopharmacol 15: 237-242. 
    Smith, H., Miller, M., Agarwal, S., Sinetti, M., Yan, C., Long, T. et al. (2000) Article title here. J Psychopharmacol 15: 237-242.

    Example - Book citations

    Lader, M. (1977) Effects of psychotropic drugs on auditory evoked potentials in man. In Desmedt, J.E. (ed), Auditory evoked potentials in man: psychopharmacology correlates of evoked potentials, Karger: Basel.

    4.1 Corresponding Author Contact details

    Provide full contact details for the corresponding author including email, mailing address and telephone numbers. Academic affiliations are required for all co-authors. These details should be presented separately to the main text of the article to facilitate anonymous peer review.

    Please also provide the email addresses for ALL authors.

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    5. Research Ethics

    When reporting experiments on human subjects, indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional or regional) or with the Declaration of Helsinki 1975, revised Hong Kong 1989. Do not use patients' names, initials or hospital numbers, especially in illustrative material. When reporting experiments on animals, indicate whether the institution's or the National Research Council's guide for, or any national law on, the care and use of laboratory animals was followed.

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    6. Publication Statement

    Papers submitted to this Journal for publication are considered on condition that they have been neither submitted elsewhere, nor published elsewhere other than in abstract form. The Editors do not enter into correspondence about papers considered unsuitable for publication; their decision is final. Requirements for publication in the Journal are in accordance with the International Committee of Medical Journal Editors' Uniform Requirements for Manuscripts Submitted to Biomedical Journals [ICMJE, 2007].

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    7. Peer review statement

    The Therapeutic Advances series adheres to a blinded peer review process in which the reviewers' names are routinely withheld from the author unless a reviewer requests a preference for his or her identity to be revealed. Authors are invited to suggest the names, affiliations and contact information of up to six individuals who may be suitable to serve as referees, but the Editors are under no obligation to use all or any of these individuals as reviewers.

    Recommeded reviewers should be experts in their fields and should be able to provide an objective assessment of the manuscript. Please be aware of any conflicts of interest when recommending reviewers. Examples of conflicts of interest include (but are not limited to) the below:

    • The reviewer should have no prior knowledge of your submission
    • The reviewer should not have recently collaborated with any of the authors
    • Reviewer nominees from the same institution as any of the authors are not permitted

    All manuscripts are reviewed initially by the Editors and only those papers that meet the scientific and editorial standards of the journal, and fit within the aims and scope of the journal, will be sent for outside review. Each research article and review manuscript is reviewed by at least two referees. All manuscripts are reviewed as rapidly as possible, and a first editorial decision is generally reached within 3 weeks of submission.

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    8. Journal contributor’s publishing agreement       

    Before publication SAGE requires the author as the rights holder to sign a Journal Contributor’s Publishing Agreement. SAGE’s Journal Contributor’s Publishing Agreement is an exclusive licence agreement which means that the author retains copyright in the work but grants SAGE the sole and exclusive right and licence to publish for the full legal term of copyright.  Exceptions may exist where an assignment of copyright is required or preferred by a proprietor other than SAGE. In this case copyright in the work will be assigned from the author to the society. For more information please visit our Frequently Asked Questions on the SAGE Journal Author Gateway.

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    9. Declaration of conflicting interests

    Within your Journal Contributor’s Publishing Agreement you will be required to make a certification with respect to a declaration of conflicting interests. It is the policy of the Therapeutic Advances series to require a declaration of conflicting interests from all authors enabling a statement to be carried within the paginated pages of all published articles.

    Please include any declaration at the end of your manuscript after any acknowledgements and prior to the references, under a heading ‘Declaration of Conflicting Interests’. If no declaration is made the following will be printed under this heading in your article: ‘None Declared’. Alternatively, you may wish to state that ‘The Author(s) declare(s) that there is no conflict of interest’. 

    When making a declaration the disclosure information must be specific and include any financial relationship that all authors of the article has with any sponsoring organization and the for-profit interests the organization represents, and with any for-profit product discussed or implied in the text of the article.

    Any commercial or financial involvements that might represent an appearance of a conflict of interest need to be additionally disclosed in the covering letter accompanying your article to assist the Editor in evaluating whether sufficient disclosure has been made within the Declaration of Conflicting Interests provided in the article.

    For more information please visit the SAGE Journal Author Gateway.

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    10. Authorship

    Papers should only be submitted for consideration once consent is given by all contributing authors. Those submitting papers should carefully check that all those who work contributed to the paper are acknowledged as contributing authors.

    The list of authors should include all those who can legitimately claim authorship. This is all those who:

    (i) Made a substantial contribution to the concept or design of the work; or acquistion, analysis or interpretation of the data,

    (ii) Drafted the article or revised it critically for important intellectual content,
    (iii) Approved the version to be published,
    (iv) Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content.

    Authors should meet the conditions of all of the points above. When a large, multicentre group has conducted the work, the group should identify the individuals who accept direct responsiblity for the manuscript. These individuals should fully meet the criteria for authorship.

    Acquistion of funding, collection of data, or general supervision of the research group alone does not constitute authorship, although all contributors who do not meet the criteria for authorship should be listed in the Acknowledgements section. Please refer to the International Committee of Medical Journal Editors (ICMJE) authorship guidelines for more information on authorship.

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    11. Plagiarism Policy

    Therapeutic Advances in Chronic Disease and SAGE take issues of copyright infringement, plagiarism or other breaches of best practice in publication very seriously. We seek to protect the rights of our authors and we always investigate claims of plagiarism or misuse of published articles. Equally, we seek to protect the reputation of the journal against malpractice. Submitted articles may be checked with duplication-checking software. Where an article, for example, is found to have plagiarised other work or included third-party copyright material without permission or with insufficient acknowledgement, or where the authorship of the article is contested, we reserve the right to take action including, but not limited to: publishing an erratum or corrigendum (correction); retracting the article; taking up the matter with the head of department or dean of the author's institution and/or relevant academic bodies or societies; or taking appropriate legal action.

     12. Writing Assistance

    Individuals who provided writing assistance, e.g. from a specialist communications company, do not qualify as authors and so should be included in the Acknowledgements section, Authors must disclose any writing assistance - including the individual's name, company and level of input - and identify the entity that paid for this assistance.

    It is not necessary to disclose use of language polishing services.

    13. Funding Acknowledgement

    To comply with the guidance for Research Funders, Authors and Publishers issued by the Research Information Network (RIN), the Therapeutic Advances series additionally requires all Authors to acknowledge their funding in a consistent fashion under a separate heading.  All research articles should have a funding acknowledgement in the form of a sentence as follows, with the funding agency written out in full, followed by the grant number in square brackets:

    This work was supported by the Medical Research Council [grant number xxx].

    Multiple grant numbers should be separated by comma and space. Where the research was supported by more than one agency, the different agencies should be separated by semi-colon, with “and” before the final funder. Thus:

    This work was supported by the Wellcome Trust [grant numbers xxxx, yyyy]; the Natural Environment Research Council [grant number zzzz]; and the Economic and Social Research Council [grant number aaaa].

    In some cases, research is not funded by a specific project grant, but rather from the block grant and other resources available to a university, college or other research institution. Where no specific funding has been provided for the research we ask that corresponding authors use the following sentence:

    This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

    Please include this information under a separate heading entitled “Funding” directly after any other Acknowledgements prior to your “Declaration of Conflicting Interests” (if applicable), any Notes and your References.

    Important note: If you have any concerns that the provision of this information may compromise your anonymity dependent on the peer review policy of this journal outlined above, you can withhold this information until final accepted manuscript.

    For more information on the guidance for Research Funders, Authors and Publishers, please visit:

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    14. Informed Consent

    Authors are required to ensure the following guidelines are followed, as recommended by the International Committee of Medical Journal Editors, Uniform Requirements for Manuscripts Submitted to Biomedical Journals. Patients have a right to privacy that should not be infringed without informed consent. Identifying information, including patients' names, initials, or hospital numbers, should not be published in written descriptions, photographs, and pedigrees unless the information is essential for scientific purposes and the patient (or parent or guardian) gives written informed consent for publication. Informed consent for this purpose requires that a patient who is identifiable be shown the manuscript to be published. Authors should identify Individuals who provide writing assistance and disclose the funding source for this assistance. Identifying details should be omitted if they are not essential. Complete anonymity is difficult to achieve, however, and informed consent should be obtained if there is any doubt. For example, masking the eye region in photographs of patients is inadequate protection of anonymity. If identifying characteristics are altered to protect anonymity, such as in genetic pedigrees, authors should provide assurance that alterations do not distort scientific meaning and editors should so note.
    When informed consent has been obtained it should be indicated in the submitted article.

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    15. Permissions 
    Authors are responsible for obtaining permission from copyright holders for reproducing any illustrations, tables, figures or lengthy quotations previously published elsewhere. For further information including guidance on fair dealing for criticism and review, please visit our Frequently Asked Questions on the SAGE Journal Author Gateway.
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     16. After acceptance

    16.1 Proofs
    We will email a PDF of the proofs to the corresponding author.

    16.2 E-Prints and Complimentary Copies
    SAGE provides authors with access to a PDF of their final article. For further information please visit  We additionally provide the corresponding author with a complimentary copy of the print issue in which the article appears up to a maximum of 5 copies for onward supply by the corresponding author to co-authors.

    16.3 SAGE Production
    At SAGE we place an extremely strong emphasis on the highest production standards possible. We attach high importance to our quality service levels in copy-editing, typesetting, printing, and online publication ( We also seek to uphold excellent author relations throughout the publication process.

    We value your feedback to ensure we continue to improve our author service levels. On publication all corresponding authors will receive a brief survey questionnaire on your experience of publishing with SAGE. 

    16.4 OnlineFirst Publication
    The Therapeutic Advances series benefits from OnlineFirst, a feature offered through SAGE’s electronic journal platform, SAGE Journals Online. It allows final revision articles (completed articles in queue for assignment to an upcoming issue) to be hosted online prior to their inclusion in a final print and online journal issue which significantly reduces the lead time between submission and publication. For more information please visit our OnlineFirst Fact Sheet

    16.5 SAGE Choice
    If you would like your article to be freely available online immediately upon publication (as some funding bodies now require), you can opt for it to be published under the SAGE Choice Scheme on payment of a publication fee. Please contact to request a SAGE Choice License Agreement. For more information on SAGE Choice options please visit

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