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Signal Transduction Insights

Signal Transduction Insights

eISSN: 11786434 | ISSN: 11786434 | Current volume: 8 | Current issue: 1

Signal Transduction Insights is an open access, peer-reviewed online journal that covers all aspects of signal transduction in cells, from molecular and intracellular to intercellular levels. The journal integrates research from various areas of biology and its applications in health.


Editor in Chief
Edgar Grinstein Heinrich Heine University Medical Center, Germany
Editorial Board
Raul Aguilar-Roblero Universidad Nacional Autónoma de México, México
Marc D. Basson North Dakota School of Medicine and the Health Sciences, USA
Alakananda Basu University of North Texas Health Science Center, Fort Worth, Texas, USA
Stuart Keith Calderwood Harvard Medical School, USA
Giuseppe Maurizio Campo University of Messina, Italy
Olivier Civelli University of California, Irvine, USA
Malka Cohen-Armon Tel-Aviv University, Israel
Hussein D. Foda Stony Brook State University, USA
Nianqiao Gong Huazhong University of Science and Technology, China
Zhenbin Hu, PhD Kansas State University, USA
Mohammad Ishaq Frederick National Laboratory for Cancer Research, USA
Estela Jacinto UMDNJ Robert Wood Johnson Medical School, USA
Michy P. Kelly University of South Carolina, USA
Eric S. Knudsen University of Arizona Cancer Center, USA
Alexander Levitzki The Hebrew University of Jerusalem, Israel
William K. Lim Universiti Malaysia Sarawak, Malaysia
Hung-Yun Lin Taipei Medical University, Taiwan
Jianhui Liu Chongqing Technology and Business University, China
Katia Cailliau Maggio University of Lille, France
Csaba Mahotka Heinrich Heine University Düsseldorf, Germany
Chris Meijer Vrije Universiteit Medical Center, The Netherlands
Isabel Merida National Center for Biotechnology/CSIC, Spain
Delvac Oceandy University of Manchester, UK
Giovanni Mario Pitari Thomas Jefferson University, USA
Prasanna Venkatesh Ramachandran Baylor College of Medicine Houston, Houston, TX, USA
Shilpa Ramani Novozymes South Asia, India
Peter Reinach SUNY College of Optometry, USA
Antonio Rodriguez-Moreno Universidad Pablo de Olavide, Spain
Praveen Roy Marshfield Clinic, USA
Shizuya Saika Wakayama Medical University, Japan
Mauro Salvi University of Padova, Italy
Debabrata Sarkar Indian Council of Agricultural Research (ICAR), India
Jay Vadgama UCLA School of Medicine, USA
Tao Wang University of Manchester, UK
Asifa K. Zaidi Johns Hopkins University School of Medicine, USA
Qing-Ping Zeng Guangzhou University of Chinese Medicine, China

This Journal is a member of the Committee on Publication Ethics.

This Journal recommends that authors follow the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals formulated by the International Committee of Medical Journal Editors (ICMJE).

Please read the guidelines below then visit the journal’s submission site to upload your manuscript. Please note that manuscripts not conforming to these guidelines may be returned.

Only manuscripts of sufficient quality that meet the aims and scope of Signal Transduction Insights will be reviewed.

As part of the submission process you will be required to warrant that you are submitting your original work, that you have the rights in the work, that you are submitting the work for first publication in the Journal and that it is not being considered for publication elsewhere and has not already been published elsewhere, and that you have obtained and can supply all necessary permissions for the reproduction of any copyright works not owned by you.

Please Read the Manuscript Submission Guidelines below before submitting your manuscript here:

  1. Open Access
  2. Article processing charge (APC)
  3. What do we publish?
    3.1 Aims & scope
    3.2 Article types
    3.3 Writing your paper
    3.3.1 Making your article discoverable 
  4. Editorial policies
    4.1 Peer Review Policy
    4.2 Authorship
    4.3 Acknowledgements
    4.4 Funding
    4.5 Declaration of conflicting interests
    4.6 Research ethics and patient consent
    4.7 Clinical Trials
    4.8 Reporting guidelines
    4.9 Data
  5. Publishing policies
    5.1 Publication ethics
    5.2 Contributor's publishing agreement
  6. Preparing your manuscript
    6.1 Word processing formats
    6.2 Artwork, figures and other graphics
    6.3 Supplementary material
    6.4 Reference style
    6.5 English language editing services
  7. Submitting your manuscript
    7.1 How to submit your manuscript
    7.2 Title, keywords and abstracts
    7.3 Information required for completing your submission
    7.4 ORCID
    7.5 Permissions
  8. On acceptance and publication
    8.1 SAGE Production
    8.2 Continuous publication
    8.3 Promoting your article
  9. Further information

1. Open Access

Signal Transduction Insights is an open access, peer-reviewed journal. Each article accepted by peer
review is made freely available online immediately upon publication, is published under a Creative
Commons license and will be hosted online in perpetuity. Publication costs of the journal are covered by
the collection of article processing charges which are paid by the funder, institution or author of each
manuscript upon acceptance. There is no charge for submitting a paper to the journal.

For general information on open access at SAGE please visit the Open Access page or view our Open
Access FAQs.

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2. Article processing charge (APC)

If, after peer review, your manuscript is accepted for publication, a one-time article processing charge
(APC) is payable. This APC covers the cost of publication and ensures that your article will be freely
available online in perpetuity under a Creative Commons license.

The article processing charge (APC) is $1,000 USD for authors in North America and £859 for authors in
all other countries.*

*The article processing charge (APC) is payable upon acceptance after peer review and is subject to value
added tax (VAT) where applicable. If the paying author/institution is based in the European Union, to
comply with European law, VAT must be added to the APC. Providing a VAT registration number will
allow an institution to avoid paying this tax, except for UK institutions. Payments can be made in GBP or

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3. What do we publish?

3.1 Aims & scope

Before submitting your manuscript to Signal Transduction Insights, please ensure you have read
the Aims & Scope

3.2 Article types

Signal Transduction Insights welcomes submissions of the following types:

1. Case Reports

  •  Case reports present interesting or unusual examples of disease, side effects,
    symptoms, treatments, pathogenesis, or unusual circumstances in medicine and
    healthcare. Articles can be accompanied by pictures if necessary—these require
    informed patient consent to publish—and should contribute to the existing
    literature on the condition they report on. Manuscripts must present out of the
    ordinary cases.

2. Commentaries

  • Commentaries discuss the findings, implications, and/or outcomes of specific
    research or wider research on a general topic. They elaborate on or offer original
    ideas about a specific paper or a widely-researched subject. Commentaries
    differ from reviews in that they present the author’s original ideas and
    suggestions instead of only collating and reporting the previous research.

3. Editorials

  • Written by the Editor-in-Chief, deputy Editor-in-Chief, Guest Editor or Associate
    Editor of a journal, editorials are intended to inform readers of changes
    concerning the journal, or to introduce supplements, special issues, or new ideas
    relevant to the journal. In limited circumstances individuals other than the
    individuals listed here may propose an editorial topic if they wish.

4. Letters to the Editor

  • Letters to the editor can be submitted on any topic relevant to the journal and
    are usually in response to an article published in the journal. They can suggest
    new subjects to be incorporated by the journal or commend and review papers
    published in the journal. We recommend that individuals considering submitting
    a letter to the editor should contact the editor in chief first to discuss their
    manuscript. Authors should be aware that letters to the editor are not always
    added to some databases/indexes. Where the editor in chief determines that a
    letter to the editor does not require peer review a 50% discount on the journal’s
    standard applicable article processing fee will apply. Otherwise the standard
    article processing fee will apply, except if the letter addresses an issue on a
    published paper typically addressed through an expression of concern or
    retraction; in such cases no fee will apply.

5. Meeting reports

  • This manuscript type reports on a meeting with specific relevance to the journal
    it is submitted to. Meetings can be international or national conferences or
    institutional seminars.

6. Original research

  • These should detail original experiments/research conducted by the authors.
    Any research on any topic is accepted, provided it falls within the aims and scope 
    of the journal. Original research must add to scientific knowledge on the subject
    and must be completed in accordance with ethical principles. Research on
    humans or animals must have applicable ethical approvals.

7. Reviews

  • A review is a detailed examination including the benefits and drawbacks of a
    medicine, therapeutic technique, computer program, policy, or anything else
    appropriate to the journal. They are substantially composed of a report on
    previous research. Authors wishing to present original ideas in addition should
    choose the Commentary type. All journals accept unsolicited review
    manuscripts for peer review.

8. Short reports

  • Short reports present new research that adds to previous studies. This can be
    reporting on the reliability or unreliability of research or informing readers of
    new factors that may influence the outcome of the study. Authors must
    acknowledge the work they build upon including any unpublished sources.
    Manuscripts should be no longer than approximately 1,000 words excluding

9. Technical advances

  • A broad-scoped category of manuscript reporting an advance within the journal's
    scope. New procedures, experiments, standard practices, or computational
    methods should be presented in technical advance articles. They report on
    significant advancements in technology that the reader will benefit from learning

3.3 Writing your paper

The SAGE Author Gateway has some general advice and on how to get published, plus links to
further resources.

3.3.1 Making your article discoverable 

When writing up your paper, think about how you can make it discoverable. The title,
keywords and abstract are key to ensuring readers find your article through search
engines such as Google. For information and guidance on how best to title your article,
write your abstract and select your keywords, have a look at this page on the Gateway:
How to Help Readers Find Your Article Online

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4. Editorial policies

4.1 Peer review policy

The journal’s policy is to have manuscripts reviewed by two expert reviewers. Signal
Transduction Insights
utilizes a single-blind peer review process in which the reviewer’s name
and information is withheld from the author. All manuscripts are reviewed as rapidly as possible,
while maintaining rigor. Reviewers make comments to the author and recommendations to the
Editor-in-Chief who then makes the final decision.

The Editor or members of the Editorial Board may occasionally submit their own manuscripts for
possible publication in the journal. In these cases, the peer review process will be managed by
alternative members of the Board and the submitting Editor / Board member will have no
involvement in the decision-making process. 

4.2 Authorship

Papers should only be submitted for consideration once consent is given by all contributing
authors. Those submitting papers should carefully check that all those whose work contributed
to the paper are acknowledged as contributing authors.
The list of authors should include all those who can legitimately claim authorship. This is all
those who:

(i) Made a substantial contribution to the concept or design of the work; or acquisition,
analysis or interpretation of data,
(ii) Drafted the article or revised it critically for important intellectual content,
(iii) Approved the version to be published,
(iv) Each author should have participated sufficiently in the work to take public
responsibility for appropriate portions of the content.

Authors should meet the conditions of all of the points above. Each author should have
participated sufficiently in the work to take public responsibility for appropriate portions of the

When a large, multicentre group has conducted the work, the group should identify the
individuals who accept direct responsibility for the manuscript. These individuals should fully
meet the criteria for authorship.

Acquisition of funding, collection of data, or general supervision of the research group alone
does not constitute authorship, although all contributors who do not meet the criteria for
authorship should be listed in the Acknowledgments section. Please refer to the International
Committee of Medical Journal Editors (ICMJE) authorship guidelines
for more information on

4.3 Acknowledgements

All contributors who do not meet the criteria for authorship should be listed in an
Acknowledgements section. Examples of those who might be acknowledged include a person
who provided purely technical help, or a department chair who provided only general support. 

4.3.1 Writing assistance

Individuals who provided writing assistance, e.g. from a specialist communications company, do
not qualify as authors and so should be included in the Acknowledgements section. Authors
must disclose any writing assistance – including the individual’s name, company and level of
input – and identify the entity that paid for this assistance.

It is not necessary to disclose use of language polishing services.

Any acknowledgements should appear first at the end of your article prior to your Declaration of
Conflicting Interests (if applicable), any notes and your References.

4.4 Funding

Signal Transduction Insights requires all authors to acknowledge their funding in a consistent
fashion under a separate heading. Please visit the Funding Acknowledgements page on the
SAGE Journal Author Gateway to confirm the format of the acknowledgment text in the event of
funding, or state that: This research received no specific grant from any funding agency in the
public, commercial, or not-for-profit sectors

4.5 Declaration of conflicting interests

It is the policy of Signal Transduction Insights to require a declaration of conflicting interests
from all authors enabling a statement to be carried within the paginated pages of all published

Please ensure that a ‘Declaration of Conflicting Interests’ statement is included at the end of
your manuscript, after any acknowledgements and prior to the references. If no conflict exists,
please state that ‘The Author(s) declare(s) that there is no conflict of interest’.

For guidance on conflict of interest statements, please see the ICMJE recommendations.

4.6 Research ethics and patient consent

Medical research involving human subjects must be conducted according to the World Medical
Association Declaration of Helsinki.

Submitted manuscripts should conform to the ICMJE Recommendations for the Conduct,
Reporting, Editing, and Publication of Scholarly Work in Medical Journals
, and all papers
reporting animal and/or human studies must state in the methods section that the relevant
Ethics Committee or Institutional Review Board provided (or waived) approval. Please ensure
that you have provided the full name and institution of the review committee, in addition to the
approval number.

For research articles, authors are also required to state in the methods section whether
participants provided informed consent and whether the consent was written or verbal.

Information on informed consent to report individual cases or case series should be included in
the manuscript text. A statement is required regarding whether written informed consent for
patient information and images to be published was provided by the patient(s) or a legally
authorized representative.

Please also refer to the ICMJE Recommendations for the Protection of Research Participants

All research involving animals submitted for publication must be approved by an ethics
committee with oversight of the facility in which the studies were conducted. The journal has
adopted the Consensus Author Guidelines on Animal Ethics and Welfare for Veterinary Journals
published by the International Association of Veterinary Editors.

4.7 Clinical trials

Signal Transduction Insights conforms to the ICMJE requirement that clinical trials are registered
in a WHO-approved public trials registry at or before the time of first patient enrolment as a
condition of consideration for publication. The trial registry name and URL, and registration
number must be included at the end of the abstract.

4.8 Reporting guidelines

The relevant EQUATOR Network reporting guidelines should be followed depending on the type
of study. For example, all randomized controlled trials submitted for publication should include
a completed CONSORT flow chart as a cited figure and the completed CONSORT checklist should
be uploaded with your submission as a supplementary file. Systematic reviews and metaanalyses
should include the completed PRISMA flow chart as a cited figure and the completed
PRISMA checklist should be uploaded with your submission as a supplementary file. The
EQUATOR wizard can help you identify the appropriate guideline.

Other resources can be found at NLM’s Research Reporting Guidelines and Initiatives.

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5. Publishing policies

5.1 Publication ethics

SAGE is committed to upholding the integrity of the academic record. We encourage authors to
refer to the Committee on Publication Ethics’ International Standards for Authors and view the
Publication Ethics page on the SAGE Author Gateway.

5.1.1 Plagiarism

Signal Transduction Insights and SAGE take issues of copyright infringement, plagiarism or other
breaches of best practice in publication very seriously. We seek to protect the rights of our
authors and we always investigate claims of plagiarism or misuse of published articles. Equally,
we seek to protect the reputation of the journal against malpractice. Submitted articles may be
checked with duplication-checking software. Where an article, for example, is found to have
plagiarized other work or included third-party copyright material without permission or with
insufficient acknowledgement, or where the authorship of the article is contested, we reserve
the right to take action including, but not limited to: publishing an erratum or corrigendum
(correction); retracting the article; taking up the matter with the head of department or dean of
the author's institution and/or relevant academic bodies or societies; or taking appropriate legal

5.1.2 Prior publication

If material has been previously published, it is not generally acceptable for publication in a SAGE
journal. However, there are certain circumstances where previously published material can be
considered for publication. Please refer to the guidance on the SAGE Author Gateway or if in
doubt, contact the Editor at the address given below.

5.2 Contributor's publishing agreement

Before publication SAGE requires the author as the rights holder to sign a Journal Contributor’s
Publishing Agreement. Signal Transduction Insights publishes manuscripts under Creative
Commons licenses
. The standard license for the journal is Creative Commons by Attribution
Non-Commercial (CC BY-NC), which allows others to re-use the work without permission as long
as the work is properly referenced and the use is non-commercial. For more information, you
are advised to visit SAGE's OA licenses page.

Alternative license arrangements are available, for example, to meet particular funder
mandates, made at the author’s request. 

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6. Preparing your manuscript

6.1 Word processing formats

The preferred format for your manuscript is Word. LaTeX files are also accepted. Word and
(La)Tex templates are available on the Manuscript Submission Guidelines page of our Author

6.2 Artwork, figures and other graphics

For guidance on the preparation of illustrations, pictures and graphs in electronic format, please
visit SAGE’s Manuscript Submission Guidelines

Figures supplied in color will appear in color online.

6.3 Supplementary material

This journal is able to host additional materials online (e.g. datasets, podcasts, videos, images
etc) alongside the full-text of the article. These will be subjected to peer-review alongside the
article. For more information please refer to our guidelines on submitting supplementary files,
which can be found within our Manuscript Submission Guidelines page. 

6.4 Reference style

Signal Transduction Insights adheres to the AMA reference style. Please review the guidelines
on AMA
to ensure your manuscript conforms to this reference style.

If you use EndNote to manage references, you can download the AMA output file here.

6.5 English language editing services

Authors seeking assistance with English language editing, translation, or figure and manuscript
formatting to fit the journal’s specifications should consider using SAGE Language Services. Visit
SAGE Language Services on our Journal Author Gateway for further information. 

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7. Submitting your manuscript

7.1 How to submit your manuscript

To submit your manuscript to Signal Transduction Insights, please visit our manuscript
submission website
. Please be sure to ensure that references are formatted with AMA reference

7.2 Title, keywords and abstracts

Please supply a title, short title, an abstract and keywords to accompany your article. The title,
keywords and abstract are key to ensuring readers find your article online through online search
engines such as Google. Please refer to the information and guidance on how best to title your
article, write your abstract and select your keywords by visiting the SAGE Journal Author
Gateway for guidelines on How to Help Readers Find Your Article Online. 

7.3 Information required for completing your submission

Provide full contact details for the corresponding author including email, mailing address and
telephone numbers. Academic affiliations are required for all co-authors. These details should
be presented separately to the main text of the article to facilitate anonymous peer review.

You will be asked to provide contact details and academic affiliations for all co-authors via the
submission system and identify who is to be the corresponding author. These details must
match what appears on your manuscript. At this stage please ensure you have included all the
required statements and declarations and uploaded any additional supplementary files
(including reporting guidelines where relevant).


As part of our commitment to ensuring an ethical, transparent and fair peer review process
SAGE is a supporting member of ORCID, the Open Researcher and Contributor ID. ORCID
provides a persistent digital identifier that distinguishes researchers from every other researcher
and, through integration in key research workflows such as manuscript and grant submission,
supports automated linkages between researchers and their professional activities ensuring that
their work is recognized.

We encourage all authors to add their ORCIDs to their SAGE Track accounts and include their
ORCIDs as part of the submission process. If you don’t already have one you can create one

7.5 Permissions

Authors are responsible for obtaining permission from copyright holders for reproducing any
illustrations, tables, figures or lengthy quotations previously published elsewhere. For further
information including guidance on fair dealing for criticism and review, please visit our
Frequently Asked Questions on the SAGE Journal Author Gateway.

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8. On acceptance and publication

If your paper is accepted for publication after peer review, you will first be asked to complete the
contributor’s publishing agreement. Once your manuscript files have been checked for SAGE Production,
the corresponding author will be asked to pay the article processing charge (APC) via a payment link.
Once the APC has been processed, your article will be prepared for publication and can appear online
within an average of 30 days. Please note that no production work will occur on your paper until the
APC has been received.

8.1 SAGE Production

Your SAGE Production Editor will keep you informed as to your article’s progress throughout the
production process. Proofs will be sent by PDF to the corresponding author and should be
returned promptly. Authors are reminded to check their proofs carefully to confirm that all
author information, including names, affiliations, sequence and contact details are correct, and
that Funding and Conflict of Interest statements, if any, are accurate. Please note that if there
are any changes to the author list at this stage all authors will be required to complete and sign
a form authorizing the change.

8.2 Online publication

One of the many benefits of publishing your research in an open access journal is the speed to
publication. With no page count constraints, your article will be published online in a fully
citable form with a DOI number as soon as it has completed the production process. At this time
it will be completely free to view and download for all. 

8.3 Promoting your article

Publication is not the end of the process! You can help disseminate your paper and ensure it is
as widely read and cited as possible. The SAGE Author Gateway has numerous resources to help
you promote your work. Visit the Promote Your Article page on the Gateway for tips and advice.
In addition, SAGE is partnered with Kudos, a free service that allows authors to explain, enrich, 
share, and measure the impact of their article. Find out how to maximize your article’s impact
with Kudos. 

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9. Further information

Any correspondence, queries or additional requests for information on the Manuscript Submission
process should be sent to the Signal Transduction Insights editorial office as follows:

Kiley Allen, Associate Publishing Editor – Open Access

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