The International Journal of Toxicology publishes timely, peer-reviewed papers on current topics important to toxicologists. Six bi-monthly issues cover a wide range of topics, including contemporary issues in toxicology, safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biomarkers, and risk assessment. The Journal also publishes invited reviews on contemporary topics, and features articles based on symposia. In addition, supplemental issues are routinely published on various special topics, including three supplements devoted to contributions from the Cosmetic Review Expert Panel.
The journal does not have submission or publication fees, and color pages are available at a greatly reduced price.
This journal is a member of the Committee on Publication Ethics (COPE).
American College of Toxicology Policy Statement on the Use of Animals in Toxicolgy
The International Journal of Toxicology publishes timely, peer-reviewed papers on current topics important to toxicologists. The journal covers a wide range of topics, including contemporary issues in toxicology, safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biomarkers, and risk assessment.
|Mary Beth Genter, PhD||University of Cincinnati, USA|
|Bruce K. Bernard, PhD||SRA Consulting, Cambridge, MD, USA|
|William J. Brock, PhD||Brock Scientific Consulting, USA|
|George E. Dearlove, PhD||Dearlove Consulting, Sherrills Ford, NC, USA|
|Marion F. Ehrich, PhD||VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, USA|
|Robert W. Kapp, Jr., PhD||BioTox, Monroe Township, NJ, USA|
|Krishna P. Allamneni, PhD||Jazz Pharmaceuticals Palo Alto, CA, USA|
|Shana Azri-Meehan, PhD||Johnson Matthey, Conshohonken, PA, USA|
|Theodore J. Baird, PhD||MPI Research, Mattawan, MI, USA|
|Sudheer R. Beedanagari, PhD||Alkermes Inc., Waltham, MA, USA|
|Lisa D. Beilke, PhD||Toxicology Solutions, Inc., San Diego, CA, USA|
|Susan Borghoff, PhD||ToxStrategies, Inc., Cary, NC, USA|
|Alan P. Brown, PhD||Novartis Institutes for Biomedical Research, MA, USA|
|Lorrene A. Buckley, PhD||Eli Lilly and Company, IN, USA|
|John A. Budny, PhD||PharmaCal, Westlake Village, CA, USA|
|Florence G. Burleson, PhD||BRT-Burleson Research Technologies, Inc., NC, USA|
|Gary R. Burleson, PhD||BRT-Burleson Research Technologies, Inc., NC, USA|
|Leigh Ann Burns Naas, PhD||Gilead Sciences, Inc., Foster City, CA, USA|
|Charleata Carter, PhD||Carter Consulting, Greensboro, NC, USA|
|Scott Coleman, PhD||Spero Therapeutics, Attleboro, MA, USA|
|David Compton, PhD||Sanofi-Aventis, Bridgewater, NJ, USA|
|Darol E. Dodd, PhD||Charles River Laboratories, Spencerville, OH, USA|
|Li-jie Fu, PhD||Shin Nippon Biomedical Labs, Ltd, Beijing, China|
|Shayne C. Gad, PhD||Gad Consulting Services, Cary, NC, USA|
|Hanan N. Ghantous, PhD||US FDA, Silver Spring, MD, USA|
|Robin C. Guy, MS||Robin Guy Consulting, LLC, Lake Forest, IL, USA|
|Bert Haenen, PhD||Janssen Research and Development, Beerse, Belgium|
|Jerry F. Hardisty||EPL Inc., Research Triangle Park, NC, USA|
|Stephen B. Harris, PhD||Stephen B. Harris Group, San Diego, CA, USA|
|Kok-Wah Hew, PhD||Takeda Global R&D, IL, USA|
|Alan M. Hoberman, PhD||Charles River Laboratories, USA|
|David W. Hobson, PhD||LoneStar PharmTox LLC, Boerne, TX, USA|
|Debie Hoivik, PhD||Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USA|
|Elaine V. Knight, PhD||National Cancer Institute, Bethesda, Maryland, USA|
|Peter J. Korytko, PhD, MBA||Preclinical GPS, Bainbridge Island, WA, USA|
|Richard W. Lane, PhD||Pepsi Co, Valhalla, NY, USA|
|Palma Ann Marone||Boston Scientific Corp., Arden Hills, MN, USA|
|Stephen B. Montgomery, PhD||Consulting Nonclinical Safety Assessment, Alpharetta, GA, USA|
|Barbara J. Mounho-Zamora, PhD||ToxStrategies, Inc., Bend, OR, USA|
|P. Balakrishna Murthy, PhD, DSc||Consultant Toxicologist, Chennai, India|
|Dennis J. Naas, BS, PMP||ProDev Consulting Services, Ltd., Poway, CA, USA|
|Kenneth J. Olivier, Jr., PhD||Acceleron Pharma Inc., Cambridge, MA, USA|
|Charles W. Qualls, Jr., DVM, PhD||Thousand Oaks, California, USA|
|Gunda Reddy, PhD||US Army CHPPM, Aberdeen Proving Ground, MD, USA|
|Mark Seaton, PhD||US FDA, Silver Spring, MD, USA|
|Viny Srinivasan, PhD, DABT, ERT||L'Oreal, Inc., USA|
|Alan H. Stokes, PhD||GSK, Rockville, MD, USA|
|Tao Wang, MD, PhD||Achaogen, San Francisco, USA|
|Adam Woolley, MSc, FRCPath||ForthTox Ltd., Linlithgow, Scotland, UK|
Average time from submission to first decision: 13 days
The International Journal of Toxicology publishes timely, peer-reviewed papers on current topics important to toxicologists. Six bi-monthly issues cover a wide range of topics, including contemporary issues in toxicology, safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biomarkers, and risk assessment. The Journal also publishes invited reviews on contemporary topics, and features articles based on symposia. In addition, supplemental issues are routinely published on various special topics, including three supplements devoted to contributions from the Cosmetic Ingredient Review Expert Panel.
All authors are now required to complete an authorship form upon submission of their article. Any author found not to be incompliance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals formulated by the International Committee on Medical Journal Editors (ICJME) and requirements for authorship will be relisted under acknowledgements.
This journal is a member of the Committee on Publication Ethics.
There are no fees associated with submitting to this journal.
Please read the guidelines below then submit your manuscripts electronically to http://mc.manuscriptcentral.com/uito. Authors will be asked to set up an online account in the SAGETRACK system, powered by ScholarOne. Please note that manuscripts not conforming to these guidelines may be returned. Only manuscripts of sufficient quality that meet the aims and scopes of IJT will be reviewed. For questions regarding submission, contact Mary Beth Genter, Editor, at email@example.com.
As part of the submission process you will be required to warrant that you are submitting your original work, that you have the rights in the work, that you are submitting the work for first publication in the Journal and that it is not being considered for publication elsewhere and ahs not already been published elsewhere, and that you have obtained and can supply all necessary permissions for the reproduction of any copyright works not owned by you.
Manuscript Submission Guidelines
International Journal of Toxicology (the Journal) is the official journal of the American College of Toxicology and is published by SAGE. The Journal publishes timely, peer-reviewed original research papers on current topics important to toxicologists. Six bi-monthly issues cover a wide range of topics, including contemporary issues in toxicology, safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biomarkers, and risk assessment. The Journal also publishes invited reviews on contemporary topics, and features articles based on symposia. In addition, supplemental issues are routinely published on various special topics, including three supplements devoted to contributions from the Cosmetic Ingredient Review Expert Panel.
The Journal does NOT publish the following: case reports, case studies, papers dealing with chemoprotection/therapeutic interventions (i.e. the protective/therapeutic effect of agent X against the toxicity of chemical Y), papers showing results with poorly characterized natural products, or papers with an ecotoxicology focus.
Peer review: Manuscripts that meet the journal requirements are peer reviewed by experts from the Journal’s Editorial Board or other qualified reviewers. Reviewers are asked to return their peer reviews within three weeks. Guidelines for reviewing manuscripts are posted on the American College of Toxicology’ website: http://www.actox.org/journal/intlJournal.asp.
Authorship: Papers should only be submitted for consideration after consent is given by all contributing authors. Those submitting papers should carefully check that all those whose work contributed to the paper are acknowledged as contributing authors. We require that author contributions are listed after the COI disclosure. Please note that authorship should conform to guidelines established by the Council on Publication Ethics: http://publicationethics.org/files/2003pdf12.pdf. A sample statement is outlined here: “XXX and YYY designed the experiments: XXX, AAA, and BBB performed the experiments; AAA, BBB, and CCC analyzed the data; ZZZ contributed reagents; XXX and CCC wrote the manuscript.” A form is provided on the Manuscript Central submission site to aid authors in outlining the contributions of each author.
Acknowledgements: Acquisition of funding, collection of data, or general supervision of the research group alone does not constitute authorship. Individuals who participated in the research but do not qualify for authorship should be listed in the Acknowledgements section of the manuscript (with the permission of that individual). Individuals who provided writing assistance do not qualify for authorship and should be included in the Acknowledgements section.
Funding: International Journal of Toxicology requires all authors to disclose their funding in a consistent fashion under a “Funding” heading. Please see the Funding Acknowledgements page on the SAGE Journal Author Gateway to confirm the format for disclosing funding. If the work was performed without any specific funding, authors should state “This research received no specific grant from any funding agency in the public, commercial, private, or not-for-profit sectors”.
Conflict of Interest (COI) disclosure: International Journal of Toxicology requires all authors to disclose any possible conflicts of interest. Sufficient disclosure may include divulging affiliation as members of industrial or governmental organizations, academic support, non-profit consulting, advocacy, and all sources of financial and material support for studies and manuscripts submitted. Please ensure that that a “Declaration of Conflicting Interest” statement is included at the end of your manuscript, after the Acknowledgements section and prior to the references. If no COI exists, please state that “The Author(s) declare(s) that there is/are not conflict(s) of interest”.
Research involving human subjects: This work must be conducted with appropriate and competent oversight, such as provided by and Institutional Review Board (IRB), ethics committee (EC), or similar independent organization and must comply with the principles of the Declaration of Helsinki (World Medical Organization; http://www.wma.net/e/policy/b3.htm). The manuscript should state in the Methods section how participants were recruited and whether participants gave informed consent; the IRB or EC approval number must be included. In addition, information must be included in the manuscript that clearly states the number of human subjects recruited and describe the study procedures and data collection techniques. The Editor reserves the right to examine such documentation. No paper will be considered for review and publication without this information from the authors.
Research involving Laboratory animals: Manuscripts submitted to International Journal of Toxicology should clearly state their compliance with the guidelines and principles listed therein and should indicate that animal protocols were reviewed and approved by an institutional panel. The American College of Toxicology Policy on the Use of Animals in Toxicology is published in Issue 1 each year, and copies may be requested from the Editor.
Data sharing: International Journal of Toxicology permits authors to share data as Supplemental files available in the online version of the Journal. Authors may also provide detailed information in their articles as to how the data may be obtained. This information should include links to third-party data repositories or detailed contact information for third- party data sources.
Publishing policies: International Journal of Toxicology is a member of the Committee on Publication Ethics (COPE). SAGE is committed to upholding the integrity of the academic record. We encourage authors to refer to the Committee on Publication Ethics’ International Standards for Authors and view the Publication Ethics page on the SAGE Author Gateway.
Plagiarism: International Journal of Toxicology and SAGE take issues of copyright infringement, plagiarism, or other breaches of best practice in publication very seriously. We seek to protect the rights of our authors and we always investigate claims of plagiarism or misuse of articles published in the journal. Equally, we seek to protect the reputation of the journal against malpractice. Submitted articles may be checked using duplication-checking software. Where an article is found to have plagiarized other work or included third-party copyright material without permission or with insufficient acknowledgement, or where authorship of the article is contested, we reserve the right to take action including, but not limited to: publishing an erratum or corrigendum (correction); retracting the article (removing it from the journal); taking up the matter with the head of department or dean of the author’s institution and/or relevant academic bodies or societies; banning the author from publication in the journal or all SAGE journals, or appropriate legal action.
Contributor’s publishing agreement: Before publication, SAGE requires the author as the rights holder to sign a Journal Contributor’s Publishing Agreement. SAGE’s Journal Contributor’s Publishing Agreement is an exclusive licence agreement which means that the author retains copyright in the work but grants SAGE the sole and exclusive right and licence to publish for the full legal term of copyright. Exceptions may exist where an assignment of copyright is required or preferred by a proprietor other than SAGE. In this case copyright in the work will be assigned from the author to the society. For more information please visit our Frequently Asked Questions on the SAGE Journal Author Gateway.
Open access and author archiving: International Journal of Toxicology offers optional open access publishing via the SAGE Choice program. For more information please visit the SAGE Choice website. For information on funding body compliance, and depositing your article in repositories, please visit SAGE Publishing Policies on our Journal Author Gateway.
Online repositories and author rights: Authors may not post the accepted version of the article (Version 2) to online repositories (including ResearchGate, Mendeley, etc.) until 12 months after publication of the article in the journal. Authors may not post the published article (Version 3) on a website or in a repository without permission from SAGE. To view your full rights as an author, visit the SAGE Publishing Policies on the Journal Author Gateway.
Permissions: Authors are responsible for obtaining permission from copyright holders for reproducing any illustrations, tables, figures or lengthy quotations previously published elsewhere. For further information including guidance on fair dealing for criticism and review, please visit our Frequently Asked Questions on the SAGE Journal Author Gateway.
Preparing your manuscript
Word processing formats: Preferred formats for the text and tables of your manuscript are Word DOC, RTF, XLS. LaTeX files are also accepted. The text should be double-spaced throughout and with a minimum of 3cm for left and right hand margins and 5cm at head and foot. Text should be standard 10 or 12 point. Word and (La)Tex templates are available on the Manuscript Submission Guidelines page of our Author Gateway.
Artwork, figures and other graphics: For guidance on the preparation of illustrations, pictures and graphs in electronic format, please visit SAGE’s Manuscript Submission Guidelines. Figures will be uploaded as individual files and should meet the following criteria:
300 dpi or higher in resolution
.jpg or .tif files
Figures supplied in color will appear in color online regardless of whether or not these illustrations are reproduced in color in the printed version. For specifically requested color reproduction in print, you will receive information regarding the costs from SAGE after receipt of your accepted article.
Supplementary material: This Journal is able to host additional materials online (e.g. datasets, podcasts, videos, images etc) with the full-text of the article. These will be subjected to peer-review alongside the article. For more information please refer to our guidelines on submitting supplementary files, which can be found within our Manuscript Submission Guidelines page.
Article layout: International Journal of Toxicology follows the American Medical Association (AMA) format for text, citations, and references. Authors submitting manuscripts to International Journal of Toxicology should consult the 10th Edition of the AMA Manual of Style.
References must be numbered sequentially in the text, and listed in numerical order at the end of the text.
Typical entry for a journal article:
Brock WJ, Woolley AP, Sugimoto T. Certification in toxicology: an international perspective of risk:benefit. Int J
Typical entry for journal article with >6 authors (list first 3, then et al.):
Politano VT, Lewis EM, Hoberman AM, et al. Evaluation of the developmental toxicity of methyl
dihydrojasmonate (MJD) in rats. Int J Toxicol. 2008;27(3):295-299.
Entry for book chapter:
Baker H, Genter MB. The olfactory system and nasal mucosa as portals of entry of viruses, drugs, and other
exogenous agents into the brain. In: Doty RL, ed. Handbook of Olfaction and Gustation. 2nd ed. New York, NY:
Marcel Dekker, Inc; 2003:549.
Submission: The following will be requested during online submission: (a) names, credentials, and complete contact information for the corresponding author; names, credentials, positions, and email addresses for all co-authors; (b) cover letter to the Editor stating explicitly that the manuscript is not under consideration by another journal; (c) abstract of 250 words or less; (d) key words; (e) abbreviations; and (f) one complete, doublespaced Microsoft Word file of the article with the following components listed in order of appearance:
Main body of the article
Materials and Methods
Acknowledgements, including source(s) of funding
Conflict(s) of interest
Please keep in mind that manuscripts will not be reviewed until all necessary information has been submitted. Articles needing extensive improvements in the English presentation will be returned to the Authors for revision. Articles not in the scope of the Journal will be rejected without review. The Editor reserves the right to request original data (including histology slides) for review.
English language editing services: Authors seeking assistance with English language editing, translation, or figure and manuscript formatting to fit the journal’s specifications should consider using SAGE Language Services. Visit SAGE Language Services on our Journal Author Gateway for further information.
Submitting your manuscript:
Manuscripts should be submitted electronically to http://mc.manuscriptcentral.com/uito. Authors will be asked to set up an online account in the SAGETRACK system, powered by ScholarOne. For questions regarding submission, contact Mary Beth Genter, Editor-in-Chief at firstname.lastname@example.org. Hard copy submissions or submissions via email to the Editor will not be acknowledged or reviewed.
IMPORTANT: Please check whether you already have an account in the system before trying to create a new one. If you have reviewed or authored for the Journal in the past, it is likely that you have previously created an account. For further guidance on submitting your manuscript online please visit ScholarOne Online Help.
Title, keywords and abstracts: Please supply a title, short title, an abstract and keywords to accompany your article. The title, keywords and abstract are key to ensuring that readers find your article online through online search engines such as Google or PubMed. Please refer to the information and guidance on how best to title your article, write your abstract and select your keywords by visiting the SAGE Journal Author Gateway for guidelines on How to Help Readers Find Your Article Online.
Corresponding author contact details: Provide full contact details for the corresponding author including email, mailing address and telephone numbers. Affiliations are required for all co-authors. Invalid email addresses will result in return of manuscripts without review.
Manuscript acceptance and publication:
SAGE Production: Your SAGE Production Editor will keep you informed as to your article’s progress throughout the production process. Proofs will be sent by PDF to the corresponding author and should be returned promptly.
Access to your published article: SAGE provides authors with online access to their final article.
Online First publication: Online First allows final revision articles (completed articles in queue for assignment to an upcoming issue) to be published online prior to their inclusion in a final journal issue which significantly reduces the lead time between submission and publication. For more information please visit our Online First Fact Sheet.
Guidelines for manuscripts describing natural products/natural products extracts: International Journal of Toxicology receives numerous submissions that focus on natural products or derivatives (most commonly extracts). In order to ensure the scientific reproducibility and quality of these submissions, the following parameters, at a minimum, must be addressed in the manuscript: (a) source and availability of material [including whether wild or cultivated]; (b) selection of material [in the case of plants, the plant selected for collection should be taxonomically the same as recommended by the national pharmacopeia or other related document]; (c) collection of the material; (d) processing and preparation of material; (e) storage conditions of the neat test substance and the dosing formulation; (f) analytic method(s) used to assure stability; (g) phytochemical analysis of the material, or other quantitative analytical evaluation that demonstrates the composition of the material. Include verification of stability and purity of the neat test substance under a verifiable method; (h) dose formulation analysis (e.g. quantitative measurement of homogeneity, stability and dose verification analysis of the test substance inthevehicleduringandunderthesametestconditions as the definitive study). Excellent guidance on preparation and testing of natural products, their extracts, etc. has been detailed by the World Health Organization and the Foundation for Medical Research, India.
Where can authors post their manuscripts? SAGE has adopted RoMEO Green compliant author archiving policy. The following applies under this new policy:
· You retain copyright in your work
· You may do whatever you wish with the version of the article you submitted to the journal (version 1).
· Once the article has been accepted for publication, you may post the accepted version (version 2) of the article on your own personal website, your department’s website or the repository of yourinstitution without any restrictions.
· You may not post the accepted version (version 2) of the article in any repository other than those listed above (i.e. you may not deposit in the repository of another institution or a subject repository) until 12 months after publication of the article in the journal.
· You may use the published article (version 3) for your own teaching needs or to supply on an individual basis to research colleagues, provided that such supply is not for commercial purposes.
· You may use the published article (version 3) in a book you write or edit any time after publication in the journal.
· You may not post the published article (version 3) on a website or in a repository without permission from SAGE.
· When posting or re-using the article please provide a link to the appropriate DOI for the published version of the article on SAGE Journals (http://online.sagepub.com)